Document Detail

Ochronosis, arthroscopy of a black knee: a case report and review of the literature.
MedLine Citation:
PMID:  17899002     Owner:  NLM     Status:  MEDLINE    
Ochronotic arthropathy is a rare condition found in patients with alkaptonuria. Due to the accumulation of homogentisic acid, cartilages get a dark discoloration and become brittle and more vulnerable to mechanical stress (Centinus et al. Rheumatol Int 3:127-131, 2004; Hamdi et al. Int Orthop 23:122-125, 1999; Phornphutkul, N Engl J Med 347:2111-2121, 2002; Thacker, Arthroscopy 19:14-17, 2003). This case report is about a patient first diagnosed for ochronosis by arthroscopy of the knee. Her brother was having similar complaints during follow-up. Both patients were prescribed to take glucosamine and chondroitine. Although no report is found in the literature, regarding the success of this therapy in patients with ochronosis, both patients reported a positive effect on articular pain and daily activities.
Martijn Raaijmaakers; Franky Steenbrugge; Carl Dierickx
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-09-25
Journal Detail:
Title:  Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA     Volume:  16     ISSN:  0942-2056     ISO Abbreviation:  Knee Surg Sports Traumatol Arthrosc     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-06-24     Revised Date:  2009-10-05    
Medline Journal Info:
Nlm Unique ID:  9314730     Medline TA:  Knee Surg Sports Traumatol Arthrosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  182-4     Citation Subset:  IM    
Department of Orthopaedic Surgery and Traumatology, Algemeen Stedelijk Ziekenhuis, Merestraat 80, 9300, Aalst, Belgium.
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MeSH Terms
Alkaptonuria / diagnosis*
Arthralgia / drug therapy,  etiology
Cartilage, Articular / injuries,  surgery
Chondroitin / therapeutic use
Glucosamine / therapeutic use
Knee Joint / pathology*
Menisci, Tibial / injuries,  surgery
Middle Aged
Ochronosis / etiology,  pathology*
Pain Measurement
Reg. No./Substance:
3416-24-8/Glucosamine; 9007-27-6/Chondroitin
Comment In:
Knee Surg Sports Traumatol Arthrosc. 2009 Oct;17(10):1270-1; author reply 1272-3   [PMID:  19756514 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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