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Ochratoxin A induced TNFα release from the isolated and blood- free perfused rat liver.
MedLine Citation:
PMID:  23605529     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ochratoxin A (OTA) a naturally occuring mycotoxin is nephrotoxic, hepatotoxic, teratogenic, embryotoxic, genotoxic, cancerogenic and immunosuppressive. Focussing on the immunemodulating effects, we found that OTA induces cytokine release from the isolated and bloodfree perfused rat liver. In the present study, we have characterized the liberation of tumor necrosis factor alpha (TNFα) by OTA and we described interactions with various mycotoxins andE.coli lipopolysaccharide (LPS).
Authors:
A Weidenbach; K Schuh; K Failing; E Petzinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycotoxin research     Volume:  16 Suppl 2     ISSN:  0178-7888     ISO Abbreviation:  Mycotoxin Res     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2013-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807334     Medline TA:  Mycotoxin Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  -    
Affiliation:
Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Justus-Liebig-University Giessen, Frankfurter Strasse 107, 35392, Giessen, Germany.
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