Document Detail

Ochratoxin A concentrations in food and feed from a region with Balkan Endemic Nephropathy.
MedLine Citation:
PMID:  12227939     Owner:  NLM     Status:  MEDLINE    
Balkan Endemic Nephropathy (BEN), a chronic renal disease of unknown aetiology, is found in geographically close areas of Bulgaria, Romania, Serbia, Croatia, Bosnia and Herzegovina, Slovenia, and the former Yugoslav Republic of Macedonia. Ochratoxin A (OTA), a secondary metabolite of Aspergillus and Penicillium species and a natural contaminant of food and feed, is a putative cause of BEN. Some studies have found a geographic covariation between OTA content in food/feed and BEN manifestation; others have not. In May 2000, using a competitive direct ELISA assay for OTA (detection limit 1 microg kg(-1)), we investigated OTA contamination in 165 samples of home-produced food (beans, potatoes, corn, wheat, flour) and feed from households in villages from the BEN region (Vratza district) of north-western Bulgaria. Samples were collected from: (a) BEN villages (n = 8), and therein from BEN households (20), and BEN-free households (16) (within-village controls, WVC households); and (b) BEN-free villages (7) and therein BEN-free households (22) (between-village controls, BVC). BEN households consistently had a higher proportion of OTA-positive samples than WVC households, but similar (for some foods) or lower (for other foods) proportions to BVC households. The proportion of OTA-positive samples was also higher in BVC than in WVC households. Furthermore, BEN households had a similar proportion of OTA-positive samples to the pooled, WVC and BVC, group of households. OTA-exposure estimates, derived from our OTA-concentration findings and the reported average per capita monthly consumption of basic foods in rural Bulgaria, showed the highest OTA intake in BEN households (1.21 microg day(-1)), versus 1.03 microg day(-1) in BVC and 0.71 microg day(-1) in WVC households. These OTA intakes are higher than those in the EU, and are close to the upper limits acceptable to several food-safety organizations. The results indicate that OTA may not alone cause BEN; only synergistically with other environmental toxicants and/or predisposing genotypes may do so.
M M Abouzied; A D Horvath; P M Podlesny; N P Regina; V D Metodiev; R M Kamenova-Tozeva; N D Niagolova; A D Stein; E A Petropoulos; V S Ganev
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Food additives and contaminants     Volume:  19     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  755-64     Citation Subset:  IM    
Neogen Corporation, Lansing, MI, USA.
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MeSH Terms
Animal Feed / analysis*
Balkan Nephropathy / etiology*
Carcinogens / analysis*,  toxicity
Case-Control Studies
Endemic Diseases
Enzyme-Linked Immunosorbent Assay
Food Analysis / methods*
Food Contamination / analysis*
Maximum Allowable Concentration
Ochratoxins / analysis*,  toxicity
Grant Support
5D43 TW 00641-04/TW/FIC NIH HHS
Reg. No./Substance:
0/Carcinogens; 0/Ochratoxins; 303-47-9/ochratoxin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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