| Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. | |
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MedLine Citation:
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PMID: 19885850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was to assess whether ETs or their metabolites ellagic acid and urolithins reach the human prostate upon consumption of ET-rich foods and to evaluate the effect on the expression of three proliferation biomarkers. Sixty-three patients with BPH or PCa were divided into controls and consumers of walnuts (35 g walnuts/day) or pomegranate (200 mL PJ/day) for 3 days before surgery. Independently of the ETs source, the main metabolite detected was urolithin A glucuronide, (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) (up to 2 ng/g) together with the traces of urolithin B glucuronide, (3-hydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) and dimethyl ellagic acid. The small number of prostates containing metabolites was likely caused by clearance of the compounds during the fasting. This was corroborated in a parallel rat study and thus the presence of higher quantities of metabolites at earlier time points cannot be discarded. No apparent changes in the expression of CDKN1A, MKi-67 or c-Myc were found after consumption of the walnuts or PJ. Our results suggest that urolithin glucuronides and dimethyl ellagic acid may be the molecules responsible for the beneficial effects of PJ against PCa. |
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Authors:
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Antonio González-Sarrías; Juan A Giménez-Bastida; María T García-Conesa; María B Gómez-Sánchez; Noelia V García-Talavera; Angel Gil-Izquierdo; Carmen Sánchez-Alvarez; Luis O Fontana-Compiano; Juan P Morga-Egea; Francisco A Pastor-Quirante; Francisco Martínez-Díaz; Francisco A Tomás-Barberán; Juan Carlos Espín |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 54 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 311-22 Citation Subset: IM |
Affiliation:
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Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Beverages / analysis Coumarins / administration & dosage, chemistry, metabolism*, urine Cyclin-Dependent Kinase Inhibitor p21 / genetics, metabolism Ellagic Acid / chemistry, metabolism*, urine Fruit* / chemistry Gene Expression Regulation, Neoplastic Humans Hydrolyzable Tannins / administration & dosage, chemistry, metabolism Intestines / microbiology Intracellular Signaling Peptides and Proteins / genetics, metabolism Juglans* / chemistry Male Middle Aged Nuclear Proteins / genetics, metabolism Plant Extracts / administration & dosage, chemistry Prostate / metabolism* Prostatic Hyperplasia / metabolism, surgery, urine Prostatic Neoplasms / metabolism*, prevention & control, surgery, urine Proto-Oncogene Proteins c-myc / genetics, metabolism Punicaceae* / chemistry RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CDKN1A protein, human; 0/Coumarins; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Hydrolyzable Tannins; 0/Intracellular Signaling Peptides and Proteins; 0/MKI67IP protein, human; 0/MYC protein, human; 0/Nuclear Proteins; 0/Plant Extracts; 0/Proto-Oncogene Proteins c-myc; 0/RNA, Messenger; 0/Tumor Markers, Biological; 1143-70-0/3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 476-66-4/Ellagic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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