Document Detail


Occurrence of a unique fucose-branched chondroitin sulfate in the body wall of a sea cucumber.
MedLine Citation:
PMID:  3142869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sulfated polysaccharides in the body wall of the sea cucumber occur as three fractions that differ markedly in molecular mass and chemical composition. The fraction containing a high molecular mass component has a high proportion of fucose and small amounts of galactose and amino sugars, whereas another fraction contains primarily a sulfated fucan. The third fraction (F-2), which represents the major portion of the sea cucumber-sulfated polysaccharides, contains approximately equimolar quantities of glucuronic acid, N-acetyl galactosamine, and fucose, and has a sulfate content higher than that in the other two fractions. The structure of fraction F-2 was examined in detail. This polysaccharide has an unusual structure composed of a chondroitin sulfate-like core, containing side chain disaccharide units of sulfated fucopyranosyl linked to approximately half of the glucuronic acid moieties through the O-3 position of the acid. These unusual fucose branches obstruct the access of chondroitinases to the chondroitin sulfate core of F-2. However, after partial acid hydrolysis, which removes the sulfated fucose residues from the polymer, fraction F-2 is degraded by chondroitinases into 6-sulfated and nonsulfated disaccharides.
Authors:
R P Vieira; P A Mourão
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  263     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-03     Completed Date:  1989-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18176-83     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrates / analysis
Chondroitin / analogs & derivatives*
Chondroitin Sulfates / isolation & purification*
Echinodermata / analysis*
Fucose / analysis*
Hydrolysis
Indicators and Reagents
Magnetic Resonance Spectroscopy
Methylation
Sea Cucumbers / analysis*
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Indicators and Reagents; 3713-31-3/Fucose; 9007-27-6/Chondroitin; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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