| Occurrence of a unique fucose-branched chondroitin sulfate in the body wall of a sea cucumber. | |
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MedLine Citation:
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PMID: 3142869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sulfated polysaccharides in the body wall of the sea cucumber occur as three fractions that differ markedly in molecular mass and chemical composition. The fraction containing a high molecular mass component has a high proportion of fucose and small amounts of galactose and amino sugars, whereas another fraction contains primarily a sulfated fucan. The third fraction (F-2), which represents the major portion of the sea cucumber-sulfated polysaccharides, contains approximately equimolar quantities of glucuronic acid, N-acetyl galactosamine, and fucose, and has a sulfate content higher than that in the other two fractions. The structure of fraction F-2 was examined in detail. This polysaccharide has an unusual structure composed of a chondroitin sulfate-like core, containing side chain disaccharide units of sulfated fucopyranosyl linked to approximately half of the glucuronic acid moieties through the O-3 position of the acid. These unusual fucose branches obstruct the access of chondroitinases to the chondroitin sulfate core of F-2. However, after partial acid hydrolysis, which removes the sulfated fucose residues from the polymer, fraction F-2 is degraded by chondroitinases into 6-sulfated and nonsulfated disaccharides. |
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Authors:
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R P Vieira; P A Mourão |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 263 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-03 Completed Date: 1989-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 18176-83 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrates / analysis Chondroitin / analogs & derivatives* Chondroitin Sulfates / isolation & purification* Echinodermata / analysis* Fucose / analysis* Hydrolysis Indicators and Reagents Magnetic Resonance Spectroscopy Methylation Sea Cucumbers / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Indicators and Reagents; 3713-31-3/Fucose; 9007-27-6/Chondroitin; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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