| Occurrence of the tumor-specific, calcium-binding protein, oncomodulin, in virally transformed normal rat kidney cells. | |
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MedLine Citation:
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PMID: 6311406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oncomodulin, an apparently tumor-specific calcium-binding protein, has been detected in many chemically induced rat hepatomas. It is now possible to detect, by radioimmunoassay and immunofluorescence, the presence of oncomodulin in normal rat kidney cells virally transformed by avian sarcoma virus. By contrast, it was not detected in uninfected, nonneoplastic normal rat kidney cells. The protein was isolated and purified by a novel high-performance liquid chromatography procedure and shown to be identical to that isolated previously from rat hepatoma. The cellular levels of oncomodulin approached the levels of calmodulin in avian sarcoma virus-transformed normal rat kidney cells, suggesting that the total calcium-binding activity of the cell may play a role in expression of the transformed phenotype. |
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Authors:
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J P Durkin; L M Brewer; J P MacManus |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 43 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5390-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis Animals Avian Sarcoma Viruses / genetics* Calcium-Binding Proteins / genetics*, isolation & purification Cell Transformation, Viral* Chromatography, High Pressure Liquid Fluorescent Antibody Technique Kidney Neoplasms / analysis Liver Neoplasms, Experimental / analysis Neoplasm Proteins / genetics*, isolation & purification Radioimmunoassay Rats |
| Grant Support | |
ID/Acronym/Agency:
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X-ROI-CA-31898/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Calcium-Binding Proteins; 0/Neoplasm Proteins; 0/oncomodulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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