| Occurrence of tubuloreticular structures and intracisternal paracrystalline inclusions in endothelial cells of tissue from different epidemiological types of Kaposi's sarcoma. | |
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MedLine Citation:
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PMID: 16028665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biopsied tissue specimens from 40 cases of classic, atypical classic, endemic, and AIDS-associated Kaposi's sarcoma (KS) were investigated by electron microscopy. To search for ultrastructural differences between non-AIDS-associated KS and AIDS-associated KS, the occurrence of the following 2 ultrastructural abnormalities of the rough-surfaced endoplasmic reticulum in KS cells was evaluated semi-quantitatively: tubuloreticular structures (TRS) and intracisternal paracrystalline inclusions (IPI). These peculiar structures were found in 23 of the 40 KS cases. Two types of TRS could be distinguished: loose TRS (LTRS) and compact ones (CTRS). LTRS were observed in endothelial cells of tissue from all the different epidemiological types of KS. CTRS were confined to AIDS-associated KS. IPI were present in endothelial tumor cells of only 3 non-AIDS-associated KS cases. The study shows that in cells of KS tissue only CTRS, but not LTRS, are an ultrastructural marker for AIDS-associated KS. |
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Authors:
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Karl-Horst Marquart |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 29 ISSN: 0191-3123 ISO Abbreviation: Ultrastruct Pathol Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-07-20 Completed Date: 2005-08-04 Revised Date: 2009-06-26 |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 85-93 Citation Subset: IM |
Affiliation:
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Institute of Molecular Virology, GSF National Research Center for Environment and Health, Neuherberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications,
pathology Adult Aged Endoplasmic Reticulum, Rough / ultrastructure* Endothelium, Vascular / ultrastructure* Female Humans Inclusion Bodies / ultrastructure* Male Microscopy, Electron, Transmission Middle Aged Sarcoma, Kaposi / blood supply*, etiology, pathology* |
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