Document Detail


Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice.
MedLine Citation:
PMID:  18344113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the contribution of singlet molecular oxygen [O(2) ((1)Delta(g))] to lipid peroxidation in vivo, this study combined gas chromatography-mass spectrometry with thin layer chromatography to analyse peroxidized lipids in the skin of hairless mice. Hydroxyoctadecenoate isomers and unconjugated hydroxyoctadecadienoate isomers derived from peroxidized oleic acid and linoleic acid, respectively, which are specific to O(2) ((1)Delta(g))-dependent oxygenation, were detected in the skin of live mice under ordinary feeding conditions. Short-term ultraviolet A (UVA)-irradiation of the skin in vivo elevated levels of the unconjugated hydroxyoctadecadienoate isomers significantly, whereas the irradiation of skin homogenate in vitro increased levels of all isomers derived from both O(2) ((1)Delta(g)) and free radical-dependent oxygenation to a much greater extent. This is the first report to demonstrate the occurrence of O(2) ((1)Delta(g))-specific oxygenation of unsaturated fatty acids in living animals.
Authors:
Yuko Minami; Kanako Yokoyama; Noriko Bando; Yoshichika Kawai; Junji Terao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research     Volume:  42     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
Affiliation:
Department of Food Science, Graduate School of Nutrition and Bioscience, The University of Tokushima, Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gas / methods
Chromatography, Thin Layer
Free Radicals*
Linoleic Acid / chemistry*
Lipid Peroxidation
Male
Mass Spectrometry / methods
Mice
Mice, Hairless
Oleic Acid / chemistry*
Oxygen / chemistry
Singlet Oxygen*
Skin / metabolism*
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Free Radicals; 112-80-1/Oleic Acid; 17778-80-2/Singlet Oxygen; 2197-37-7/Linoleic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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