|Occurrence of serious bacterial infection in infants aged 60 days or younger with an apparent life-threatening event.|
|PMID: 19116498 Owner: NLM Status: MEDLINE|
|OBJECTIVE: To describe the occurrence of serious bacterial infections (SBIs) in well-appearing, afebrile infants aged 60 days or younger with an apparent life-threatening event (ALTE). STUDY DESIGN: We retrospectively reviewed microbiologic testing in a cohort of well-appearing, afebrile infants aged 60 days or younger who presented with an ALTE to a children's hospital emergency department between January 2002 and July 2005. All patients were admitted and followed up for 6 months. Comparisons were made among those who did and did not undergo microbiologic testing and full sepsis evaluation (blood, urine, and cerebrospinal fluid) and those who did and did not have an SBI. RESULTS: Of 182 patients, 112 (61.5%) underwent microbiologic testing, and 53 (29.1%) had a full sepsis evaluation. Five patients (2.7%; 95% confidence interval, 0.9%-6.3%) had an SBI including 3 positive results in blood cultures, 1 positive result in urine culture, and 1 positive result for pertussis by polymerase chain reaction. No patient had a positive result in cerebrospinal fluid culture (95% confidence interval, 0%-5.7%). Patients with a history of prematurity were more likely to have an SBI (6.7% vs. 0.8%, P = 0.04). CONCLUSIONS: Serious bacterial infection occurred in 2.7% of well-appearing, afebrile infants aged 60 days or younger with an ALTE. Prematurity was associated with having an SBI. For premature infants aged 60 days or younger who present with an ALTE, an evaluation for SBI should be strongly considered.|
|Noel S Zuckerbraun; Arezoo Zomorrodi; Raymond D Pitetti|
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|Type: Journal Article|
|Title: Pediatric emergency care Volume: 25 ISSN: 1535-1815 ISO Abbreviation: Pediatr Emerg Care Publication Date: 2009 Jan|
|Created Date: 2009-01-20 Completed Date: 2009-04-24 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 8507560 Medline TA: Pediatr Emerg Care Country: United States|
|Languages: eng Pagination: 19-25 Citation Subset: IM|
|Department of Pediatrics, Division of Pediatric Emergency Medicine, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh 15213, USA. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Apnea / epidemiology
Bacteremia / epidemiology
Bacterial Infections / diagnosis, epidemiology*
Bacteriuria / epidemiology
Cerebrospinal Fluid / microbiology
Diagnostic Tests, Routine
Emergencies / epidemiology*
Emergency Service, Hospital / statistics & numerical data
Flushing / epidemiology
Hospitals, Pediatric / statistics & numerical data
Infant, Premature, Diseases / epidemiology*
Muscle Hypotonia / epidemiology
Pallor / epidemiology
Pennsylvania / epidemiology
Sepsis / diagnosis, epidemiology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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