Document Detail

Occurrence of serious bacterial infection in infants aged 60 days or younger with an apparent life-threatening event.
MedLine Citation:
PMID:  19116498     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the occurrence of serious bacterial infections (SBIs) in well-appearing, afebrile infants aged 60 days or younger with an apparent life-threatening event (ALTE). STUDY DESIGN: We retrospectively reviewed microbiologic testing in a cohort of well-appearing, afebrile infants aged 60 days or younger who presented with an ALTE to a children's hospital emergency department between January 2002 and July 2005. All patients were admitted and followed up for 6 months. Comparisons were made among those who did and did not undergo microbiologic testing and full sepsis evaluation (blood, urine, and cerebrospinal fluid) and those who did and did not have an SBI. RESULTS: Of 182 patients, 112 (61.5%) underwent microbiologic testing, and 53 (29.1%) had a full sepsis evaluation. Five patients (2.7%; 95% confidence interval, 0.9%-6.3%) had an SBI including 3 positive results in blood cultures, 1 positive result in urine culture, and 1 positive result for pertussis by polymerase chain reaction. No patient had a positive result in cerebrospinal fluid culture (95% confidence interval, 0%-5.7%). Patients with a history of prematurity were more likely to have an SBI (6.7% vs. 0.8%, P = 0.04). CONCLUSIONS: Serious bacterial infection occurred in 2.7% of well-appearing, afebrile infants aged 60 days or younger with an ALTE. Prematurity was associated with having an SBI. For premature infants aged 60 days or younger who present with an ALTE, an evaluation for SBI should be strongly considered.
Noel S Zuckerbraun; Arezoo Zomorrodi; Raymond D Pitetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric emergency care     Volume:  25     ISSN:  1535-1815     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-20     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Department of Pediatrics, Division of Pediatric Emergency Medicine, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh 15213, USA.
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MeSH Terms
Airway Obstruction / epidemiology
Apnea / epidemiology
Bacteremia / epidemiology
Bacterial Infections / diagnosis,  epidemiology*
Bacteriuria / epidemiology
Cerebrospinal Fluid / microbiology
Diagnostic Tests, Routine
Emergencies / epidemiology*
Emergency Service, Hospital / statistics & numerical data
Flushing / epidemiology
Follow-Up Studies
Hospitals, Pediatric / statistics & numerical data
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*
Muscle Hypotonia / epidemiology
Pallor / epidemiology
Pennsylvania / epidemiology
Retrospective Studies
Sepsis / diagnosis,  epidemiology

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