Document Detail

Occurrence of placental abruption in relatives.
MedLine Citation:
PMID:  19191777     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to assess the recurrence of placental abruption by severity, comparing the risk in a woman with that of recurrence in her sister and in the partner of her brother. DESIGN: Prospective observational study. SETTING: General population. POPULATION: Population-based study based on records of pregnancies from the Medical Birth Registry of Norway; 377.902 sisters with 767 395 pregnancies, 168,142 families incorporating 2-10 sisters, and 346,385 brothers with 717,604 pregnancies in their partners were identified. METHODS: Placental abruption with preterm birth, birthweight below 2500 g or perinatal death was defined as severe, other cases as mild. Because of the nested family data structure, multilevel multivariate regression was used. MAIN OUTCOME MEASURES: Placental abruption (severe and mild). RESULTS: Adjusted odds ratios of recurrence of mild and severe abruption were 6.5 (1.7%) and 11.5 (3.8%), respectively, compared with risks of 0.2 and 0.3% in the total population. After a severe abruption, odds ratios in her sisters were 1.7-2.1, whereas mild abruption produced no increased recurrence in sisters. The estimated heritability between sisters of severe abruption was 16%. No excess rate of abruption was observed between sisters and brothers' partners, between brothers' partners, or from brothers' partners to sisters. The odds ratios for a third abruption after a second abruption and a second severe abruption were 38.7 (19%) and 50.1 (24%), respectively. CONCLUSIONS: The recurrence risk of placental abruption in the same woman was higher after severe than mild abruption. Severe abruption was associated with a two-fold risk in sisters. Pregnancies following a second abruption should be considered very high risk.
S Rasmussen; L M Irgens
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Publication Detail:
Type:  Journal Article     Date:  2009-02-04
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-05-21     Revised Date:  2009-05-27    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  AIM; IM    
Medical Birth Registry of Norway, Locus of Registry Based Epidemiology, Institute of Community Medicine and Primary Health Care, University of Bergen and Norwegian Institute of Public Health, Bergen, Norway.
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MeSH Terms
Abruptio Placentae / genetics*
Infant, Newborn
Infant, Small for Gestational Age
Multivariate Analysis
Obstetric Labor, Premature
Odds Ratio
Prospective Studies
Reproductive History
Risk Factors
Young Adult
Erratum In:
BJOG. 2009 May;116(6):870

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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