| Occurrence of para-aminobenzoic acid and benzocaine as contaminants in sunscreen agents of para-aminobenzoic acid type. | |
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MedLine Citation:
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PMID: 6335917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Para-aminobenzoic acid (PABA) and some of its esters, such as amyl para-dimethylaminobenzoate, ethyl 4-bis(hydroxypropyl)aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate and glyceryl para-aminobenzoate are used as sunscreen agents. Methods for separating PABA and the 5 mentioned PABA esters by thin layer chromatography and high pressure liquid chromatography (HPLC) are presented. Contamination with PABA and benzocaine were measured quantitatively by the HPLC technique in samples of the 4 PABA esters, using different brands and different batches of the same brand. PABA was detected in all 12 samples examined and benzocaine in 11. The degree of contamination was batch-dependent. Minimal amounts of PABA and benzocaine were found in most batches but in glyceryl para-aminobenzoate both substances were present at a level above 0.1% (w/w). High levels of benzocaine were also detected in batches of ethyl 4-bis(hydroxypropyl)-aminobenzoate. |
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Authors:
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M Bruze; S Fregert; B Gruvberger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Photo-dermatology Volume: 1 ISSN: 0108-9684 ISO Abbreviation: Photodermatol Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-06-06 Completed Date: 1985-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8407997 Medline TA: Photodermatol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 277-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobenzoic Acid
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analysis* Aminobenzoic Acids / analysis* Benzocaine / analysis* Chromatography, High Pressure Liquid Chromatography, Thin Layer Drug Contamination* Esters Sunscreening Agents / analysis*, standards |
| Chemical | |
Reg. No./Substance:
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0/Aminobenzoic Acids; 0/Esters; 0/Sunscreening Agents; 150-13-0/4-Aminobenzoic Acid; 94-09-7/Benzocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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