Document Detail

Occurrence of para-aminobenzoic acid and benzocaine as contaminants in sunscreen agents of para-aminobenzoic acid type.
MedLine Citation:
PMID:  6335917     Owner:  NLM     Status:  MEDLINE    
Para-aminobenzoic acid (PABA) and some of its esters, such as amyl para-dimethylaminobenzoate, ethyl 4-bis(hydroxypropyl)aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate and glyceryl para-aminobenzoate are used as sunscreen agents. Methods for separating PABA and the 5 mentioned PABA esters by thin layer chromatography and high pressure liquid chromatography (HPLC) are presented. Contamination with PABA and benzocaine were measured quantitatively by the HPLC technique in samples of the 4 PABA esters, using different brands and different batches of the same brand. PABA was detected in all 12 samples examined and benzocaine in 11. The degree of contamination was batch-dependent. Minimal amounts of PABA and benzocaine were found in most batches but in glyceryl para-aminobenzoate both substances were present at a level above 0.1% (w/w). High levels of benzocaine were also detected in batches of ethyl 4-bis(hydroxypropyl)-aminobenzoate.
M Bruze; S Fregert; B Gruvberger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Photo-dermatology     Volume:  1     ISSN:  0108-9684     ISO Abbreviation:  Photodermatol     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8407997     Medline TA:  Photodermatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  IM    
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MeSH Terms
4-Aminobenzoic Acid / analysis*
Aminobenzoic Acids / analysis*
Benzocaine / analysis*
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Drug Contamination*
Sunscreening Agents / analysis*,  standards
Reg. No./Substance:
0/Aminobenzoic Acids; 0/Esters; 0/Sunscreening Agents; 150-13-0/4-Aminobenzoic Acid; 94-09-7/Benzocaine

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