| Occurrence of neurolepric malignant syndrome on trihexphenidyl discontinuation. | |
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MedLine Citation:
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PMID: 21584140 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The neuroleptic malignant syndrome (NMS) commonly occurs on treatment with neuroleptics, it is also reported in patients who suddenly stop drugs like levodopa, amitriptyline and imipramine. We report a case of NMS, which occurred in a patient on lithium, haloperidol and trihexyphenidyl (THP) after sudden discontinuation of THP. The cholinergic system, through its effect on the dopaminergic system, may play a role in the genesis of NMS. Alternatively, anticholinergic withdrawal may produce extrapyramidal symptoms (EPS), and the consequent alteration in food and fluid intake may produce electrolyte imbalance which increases the risk for NMS. |
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Authors:
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J P Alexander; R M Thomas; A Das |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of psychiatry Volume: 38 ISSN: 0019-5545 ISO Abbreviation: Indian J Psychiatry Publication Date: 1996 Oct |
Date Detail:
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Created Date: 2011-05-17 Completed Date: 2011-07-14 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0013255 Medline TA: Indian J Psychiatry Country: India |
Other Details:
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Languages: eng Pagination: 250-3 Citation Subset: - |
Affiliation:
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P. John Alexander, M.D., Associate Professor, Department of Psychiatry, Kasturba Medical College, Manipal - 576 119. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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