| Occurrence and neuroendocrine role of D-aspartic acid and N-methyl-D-aspartic acid in Ciona intestinalis. | |
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MedLine Citation:
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PMID: 14527686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Probes for the occurrence of endogenous D-aspartic acid (D-Asp) and N-methyl-D-aspartic acid (NMDA) in the neural complex and gonads of a protochordate, the ascidian Ciona intestinalis, have confirmed the presence of these two excitatory amino acids and their involvement in hormonal activity. A hormonal pathway similar to that which occurs in vertebrates has been discovered. In the cerebral ganglion D-Asp is synthesized from L-Asp by an aspartate racemase. Then, D-Asp is transferred through the blood stream into the neural gland where it gives rise to NMDA by means of an NMDA synthase. NMDA, in turn, passes from the neuronal gland into the gonads where it induces the synthesis and release of a gonadotropin-releasing hormone (GnRH). The GnRH in turn modulates the release and synthesis of testosterone and progesterone in the gonads, which are implicated in reproduction. |
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Authors:
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Antimo D'Aniello; Patrizia Spinelli; Antonietta De Simone; Salvatore D'Aniello; Margherita Branno; Francesco Aniello; George H Fisher; Maria M Di Fiore; Rakesh K Rastogi |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 552 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-10-06 Completed Date: 2003-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 193-8 Citation Subset: IM |
Affiliation:
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Laboratory of Neurobiology, Stazione Zoologica 'A. Dohrn', Villa Comunale, 80121 Naples, Italy. daniello@szn.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartic Acid / chemistry, physiology* Ciona intestinalis / metabolism*, physiology Female Gonadotropin-Releasing Hormone / physiology Gonads / metabolism Invertebrate Hormones / chemistry, physiology Male N-Methylaspartate / chemistry, physiology* Neurosecretory Systems / physiology Progesterone / biosynthesis Reproduction Stereoisomerism Testosterone / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Invertebrate Hormones; 33515-09-2/Gonadotropin-Releasing Hormone; 56-84-8/Aspartic Acid; 57-83-0/Progesterone; 58-22-0/Testosterone; 6384-92-5/N-Methylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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