Document Detail

Occurrence and neuroendocrine role of D-aspartic acid and N-methyl-D-aspartic acid in Ciona intestinalis.
MedLine Citation:
PMID:  14527686     Owner:  NLM     Status:  MEDLINE    
Probes for the occurrence of endogenous D-aspartic acid (D-Asp) and N-methyl-D-aspartic acid (NMDA) in the neural complex and gonads of a protochordate, the ascidian Ciona intestinalis, have confirmed the presence of these two excitatory amino acids and their involvement in hormonal activity. A hormonal pathway similar to that which occurs in vertebrates has been discovered. In the cerebral ganglion D-Asp is synthesized from L-Asp by an aspartate racemase. Then, D-Asp is transferred through the blood stream into the neural gland where it gives rise to NMDA by means of an NMDA synthase. NMDA, in turn, passes from the neuronal gland into the gonads where it induces the synthesis and release of a gonadotropin-releasing hormone (GnRH). The GnRH in turn modulates the release and synthesis of testosterone and progesterone in the gonads, which are implicated in reproduction.
Antimo D'Aniello; Patrizia Spinelli; Antonietta De Simone; Salvatore D'Aniello; Margherita Branno; Francesco Aniello; George H Fisher; Maria M Di Fiore; Rakesh K Rastogi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  552     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-06     Completed Date:  2003-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Laboratory of Neurobiology, Stazione Zoologica 'A. Dohrn', Villa Comunale, 80121 Naples, Italy.
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MeSH Terms
Aspartic Acid / chemistry,  physiology*
Ciona intestinalis / metabolism*,  physiology
Gonadotropin-Releasing Hormone / physiology
Gonads / metabolism
Invertebrate Hormones / chemistry,  physiology
N-Methylaspartate / chemistry,  physiology*
Neurosecretory Systems / physiology
Progesterone / biosynthesis
Testosterone / biosynthesis
Reg. No./Substance:
0/Invertebrate Hormones; 33515-09-2/Gonadotropin-Releasing Hormone; 56-84-8/Aspartic Acid; 57-83-0/Progesterone; 58-22-0/Testosterone; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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