Document Detail

Occurrence of myeloma in a chronic lymphocytic leukemia patients after response to differentiation therapy with interleukin-4.
MedLine Citation:
PMID:  9031095     Owner:  NLM     Status:  MEDLINE    
The occurrence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in a single individual is rare, and the clonal relationship between the two neoplasms is unclear. We describe here a patient with CLL who developed symptoms of MM while responding to experimental therapy with interleukin-4 (IL-4). This patient was treated with 2-chlorodeoxyadenosine (2-CDA), and had a response in both malignancies.
D Makower; U Venkatraj; J P Dutcher; P H Wiernik
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  23     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-11     Completed Date:  1997-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  617-9     Citation Subset:  IM    
Department of Oncology, Albert Einstein Cancer Center, Bronx, New York, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*,  therapeutic use*
Cell Differentiation / drug effects
Cladribine / therapeutic use
Interleukin-4 / adverse effects*,  therapeutic use*
Leukemia, Lymphocytic, Chronic, B-Cell / chemically induced*,  complications,  drug therapy
Middle Aged
Multiple Myeloma / complications,  drug therapy*
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 207137-56-2/Interleukin-4; 4291-63-8/Cladribine

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