Document Detail

Occurrence of menses or pregnancy after cessation of a continuous oral contraceptive.
MedLine Citation:
PMID:  17658522     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the time to return to spontaneous menses in women after 1 year of daily continuous levonorgestrel (LNG) 90 microg/ethinyl E(2) (EE) 20 microg. DESIGN: Observational study. SETTING: Gynecologic and primary care practices. PATIENT(S): Women aged 18-49 years with a history of regular menstrual cycles. After participation in an open-label, continuous oral contraceptive (OC) trial for at least 6 months, participants agreed to enroll in a separate study of the return to menses or pregnancy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to return to spontaneous menses or pregnancy. RESULT(S): The 198 subjects had a mean age of 30.4 +/- 6.6 years with 72% white, 13% Hispanic, and 7% African American. The mean duration of continuous LNG/EE treatment before enrollment was 349 +/- 41 days. Of the 187 (94%) subjects who completed this study, 181 returned to spontaneous menses and 4 became pregnant within 90 days after the last dose of LNG 90 microg/EE 20 microg. The median time to return to menses in the completer population was 32 days, and the incidence of spontaneous menses or pregnancy at day < or = 90 was 98.9%. The duration of amenorrhea during continuous LNG/EE use before stopping treatment was unrelated to the time to the return to menses. CONCLUSIONS: Spontaneous menses or pregnancy occurred in 98.9% of women after cessation of continuous LNG/EE.
Anne R Davis; Robin Kroll; Barbara Soltes; Nan Zhang; Gary S Grubb; Ginger D Constantine
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-07-20
Journal Detail:
Title:  Fertility and sterility     Volume:  89     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1059-63     Citation Subset:  IM    
College of Physicians & Surgeons, Department OB/GYN, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Contraceptives, Oral, Synthetic / adverse effects,  pharmacology*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Estrogens / adverse effects,  pharmacology*
Ethinyl Estradiol / adverse effects,  pharmacology*
Fertility / drug effects*,  physiology
Follow-Up Studies
Hypothalamo-Hypophyseal System / drug effects,  physiology
Levonorgestrel / adverse effects,  pharmacology*
Menstruation / drug effects*,  physiology
Middle Aged
Ovary / drug effects,  physiology
Regression Analysis
Time Factors
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 0/Estrogens; 57-63-6/Ethinyl Estradiol; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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