Document Detail


Occurrence of extracellular hyaluronic acid and hyaluronatlyase in streptococci of groups A, B, C, and G.
MedLine Citation:
PMID:  8946697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Streptococci of serological groups A (GAS), B (GBS), C (GCS) and G (GGS) were examined in vitro using an optimized medium in respect of their ability to produce hyaluronic acid (HA) and hyaluronatlyase (HY). In this study, 614 GAS (including 123 streptococcal toxic shock syndrome strains, STSS), 247 GBS, 225 GCS and 143 GGS were investigated in qualitative and quantitative tests. Only 4% of GAS and 2.7% of GCS were able to express HA. In contrast to GAS, isolates of GCS showed a highly specific HA formation (to 1 g HA/g dry biomass). In all strains of GBS and GGS, not even a single isolate was positive for HA. HY expression was detectable in all four serological groups. In GAS, only 12.5% of strains were positive; the most common types being 22 and 4, whereas in GBS, GCS and GGS, 72.1%, 84% and 85.3% of isolates, respectively, could be reported as positive. The data suggest that the HA capsule only plays a secondary role in infections caused by GAS strains pathogenic for humans.
Authors:
E Günther; J H Ozegowski; W Köhler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Bakteriologie : international journal of medical microbiology     Volume:  285     ISSN:  0934-8840     ISO Abbreviation:  Zentralbl. Bakteriol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  9203851     Medline TA:  Zentralbl Bakteriol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  64-73     Citation Subset:  IM    
Affiliation:
University of Jena, Institute of Experimental Microbiology, Germany.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / analysis*
Hyaluronic Acid / analysis*
Streptococcus / metabolism*
Streptococcus agalactiae / metabolism*
Streptococcus pyogenes / metabolism*
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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