Document Detail

Occurrence of congenital syphilis after maternal treatment with azithromycin during pregnancy.
MedLine Citation:
PMID:  17589329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy of azithromycin in preventing congenital syphilis. METHOD: Five pregnant women with syphilis who were allergic to penicillin were given azithromycin, 1 g daily orally or intravenously, in different hospitals. The duration of the therapy ranged from 1 day to 10 days. A second course of therapy was provided at 28 weeks gestation. The babies were given a physical examination and blood test for serum rapid plasma reagin test (RPR), treponema pallidum hemagglutination test (TPHA), and fluorescent treponemal antibody adsorption test (FTA-ABS-19-sIgM) within three months after birth. RESULTS: Five infants born to these mothers developed skin rashes. Four of the infants had hepatomegaly and one showed osteochondritis. The tests RPR, TPHA, and FTA-ABS-19-sIgM were positive. The RPR titers varied from 1:64 to 1:256 and the babies were diagnosed with congenital syphilis. They were successfully treated with penicillin. CONCLUSIONS: Successful therapy for syphilis during pregnancy demands maternal care as well as prevention or cure of congenital infection. The failure of azithromycin in preventing congenital syphilis in our report suggests that azithromycin should not be recommended as an alternative in treating syphilitic pregnant women or fetal syphilis.
Pingyu Zhou; Yihong Qian; Jinhua Xu; Zhiying Gu; Kanghuang Liao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  34     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-4     Citation Subset:  IM    
Department of STD Institute, Shanghai Skin and STD Hospital, Shanghai, China.
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MeSH Terms
Administration, Oral
Anti-Bacterial Agents / administration & dosage,  therapeutic use
Azithromycin / administration & dosage,  therapeutic use
China / epidemiology
Drug Administration Schedule
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Infusions, Intravenous
Pregnancy Complications, Infectious / blood,  epidemiology*,  etiology,  prevention & control*
Prenatal Care
Syphilis / blood,  epidemiology*,  etiology,  prevention & control*,  transmission
Syphilis Serodiagnosis
Syphilis, Congenital / blood,  epidemiology,  etiology,  prevention & control
Reg. No./Substance:
0/Anti-Bacterial Agents; 83905-01-5/Azithromycin

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