Document Detail

Occurrence and clinical significance of endocardial late potentials and fractionations in idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  3342148     Owner:  NLM     Status:  MEDLINE    
In order to assess the occurrence and clinical significance of abnormal electrograms in idiopathic dilated cardiomyopathy, endocardial electrode mapping during sinus rhythm and programmed ventricular stimulation were performed in 52 patients with or without clinical ventricular tachycardia. Abnormal endocardial electrograms were recorded in 77% of the patients and were diffusely distributed over the entire left ventricular endocardium. No relation could be established between the occurrence of late potentials or fractionations and clinical or induced arrhythmias. Endomyocardial biopsy samples were taken from 20 patients and showed that reduced myofibril volume fraction was related to the occurrence of abnormal endocardial electrograms. Neither induced arrhythmias nor the presence of late potentials or fractionations identified patients who died of sudden cardiac death during the mean (SD) follow up of 33 (11) months. Thus abnormal endocardial electrograms recorded during sinus rhythm in idiopathic dilated cardiomyopathy may only be interpreted as being a sign of damage to the myocardial cells.
B D Gonska; K P Bethge; H R Figulla; H Kreuzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  59     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-25     Completed Date:  1988-03-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  AIM; IM    
Department of Cardiology, University of Göttingen, Federal Republic of Germany.
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MeSH Terms
Action Potentials
Arrhythmias, Cardiac / physiopathology
Cardiomyopathy, Dilated / pathology,  physiopathology*
Endocardium / pathology,  physiopathology*
Heart Ventricles / physiopathology
Middle Aged
Myocardium / pathology
Prospective Studies

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