Document Detail


Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam.
MedLine Citation:
PMID:  15355492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the brain tissues of the Chamorro people of Guam who died of amyotrophic lateral sclerosis/Parkinsonism dimentia complex (ALS/PDC) for the neurotoxin beta-methylamino-l-alanine (BMAA). We used validated high-pressure liquid chromatography and liquid chromatography-mass spectrometry analyses to test well-characterized archival tissues of the superior frontal gyrus from eight Chamorros from Guam and a comparison group of 15 Canadians. BMAA was found as a free amino acid in 83% of Chamorro ALS/PDC patients (3-10 microg/g) as a protein-associated amino acid in 100% of the Chamorro individuals (149-1190 microg/g). Both forms of BMAA were also found at comparable levels in two Canadians who died of progressive neurodegenerative disease. BMAA, which is produced by cyanobacteria, may be associated with some cases of neurodegenerative disease.
Authors:
S J Murch; P A Cox; S A Banack; J C Steele; O W Sacks
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  110     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-09     Completed Date:  2004-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  267-9     Citation Subset:  IM    
Affiliation:
Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Amino Acids, Diamino / analysis*
Amyotrophic Lateral Sclerosis / etiology,  metabolism*
Bacterial Toxins / analysis*
Case-Control Studies
Dementia / etiology,  metabolism*
Female
Frontal Lobe / chemistry
Guam
Humans
Male
Marine Toxins / analysis*
Microcystins
Middle Aged
Neurotoxins / analysis*
Parkinsonian Disorders / etiology,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids, Diamino; 0/Bacterial Toxins; 0/Marine Toxins; 0/Microcystins; 0/Neurotoxins; 0/cyanobacterial toxin; 16676-91-8/alpha-amino-beta-methylaminopropionate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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