Document Detail


Occurrence of IgE-bearing epidermal Langerhans cells in atopic eczema: a study of the time course of the lesions and with regard to the IgE serum level.
MedLine Citation:
PMID:  2474029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uninvolved and lesional skin of untreated and treated patients with atopic eczema has been investigated immunohistochemically to determine the conditions in which IgE-bearing CD1a+ Langerhans cells/indeterminate cells (LC/IC) occur in this disease. IgE-bearing epidermal dendritic cells were present in patients with elevated IgE serum level (greater than 300 UI/ml) and the staining pattern was stronger in lesional skin. On double immunostaining, a subpopulation of CD1a+ LC/IC was found not to bear IgE molecules as determined by the ratio IgE+/CD1a+ cells on serial sections as well. The ratio IgE+/CD1a+ cells decreased in patients who underwent a local therapy with glucocorticosteroids. These results suggest that the expression of IgE receptors and/or binding of IgE molecules on epidermal LC/IC in atopic eczema may be controlled by a complex network of mediators from the epidermis or the inflammatory infiltrate, or both, and that this phenomenon could be down regulated by glucocorticosteroids.
Authors:
T Bieber; B Dannenberg; J C Prinz; E P Rieber; W Stolz; O Braun-Falco; J Ring
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  93     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ludwig-Maximilians University, Munich, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD1
Antigens, Differentiation / immunology
Dermatitis, Atopic / blood,  metabolism*,  pathology
Epidermis / metabolism*,  pathology
Humans
Immunoglobulin E / metabolism*
Immunohistochemistry
Langerhans Cells / metabolism*,  pathology
Time Factors
Chemical
Reg. No./Substance:
0/Antigens, CD1; 0/Antigens, Differentiation; 37341-29-0/Immunoglobulin E

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