| Occurrence of IgE-bearing epidermal Langerhans cells in atopic eczema: a study of the time course of the lesions and with regard to the IgE serum level. | |
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MedLine Citation:
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PMID: 2474029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uninvolved and lesional skin of untreated and treated patients with atopic eczema has been investigated immunohistochemically to determine the conditions in which IgE-bearing CD1a+ Langerhans cells/indeterminate cells (LC/IC) occur in this disease. IgE-bearing epidermal dendritic cells were present in patients with elevated IgE serum level (greater than 300 UI/ml) and the staining pattern was stronger in lesional skin. On double immunostaining, a subpopulation of CD1a+ LC/IC was found not to bear IgE molecules as determined by the ratio IgE+/CD1a+ cells on serial sections as well. The ratio IgE+/CD1a+ cells decreased in patients who underwent a local therapy with glucocorticosteroids. These results suggest that the expression of IgE receptors and/or binding of IgE molecules on epidermal LC/IC in atopic eczema may be controlled by a complex network of mediators from the epidermis or the inflammatory infiltrate, or both, and that this phenomenon could be down regulated by glucocorticosteroids. |
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Authors:
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T Bieber; B Dannenberg; J C Prinz; E P Rieber; W Stolz; O Braun-Falco; J Ring |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 93 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-01 Completed Date: 1989-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 215-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Ludwig-Maximilians University, Munich, F.R.G. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD1 Antigens, Differentiation / immunology Dermatitis, Atopic / blood, metabolism*, pathology Epidermis / metabolism*, pathology Humans Immunoglobulin E / metabolism* Immunohistochemistry Langerhans Cells / metabolism*, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1; 0/Antigens, Differentiation; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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