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Occurrence of Disseminated Intravascular Coagulation in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Pneumonia in the Rat.
MedLine Citation:
PMID:  23835989     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Intensity of inflammatory reaction in tissue or organ structures depends on the efficiency of homeostatic mechanisms of the organism which limit the extent of this reaction. In studies on the dynamics of inflammatory reaction in induced pneumonia after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the occurrence of disseminated intravascular coagulation (DIC) has been observed. In this article we evaluated the DIC syndrome in regard to histopathological assessment and laboratory diagnostics of blood. The evaluation indicates that some hematologic indicators (RBC, HCT, and HGB) decreased in the experimental inflammatory reaction, which might be associated with erythrocyte hemolysis in the inflammatory focus and erythrocyte elimination from circulation as a result of DIC. There also were shifts in the number of various leukocyte forms due likely to the accumulation of particular cells in the inflammatory focus. Histopathological assessment of the inflammatory focus revealed the process of hepatization and the occurrence of DIC.
Authors:
I Calkosinski; J Rosinczuk-Tonderys; M Dobrzynski; L Palka; J Bazan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  788     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-07-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-92     Citation Subset:  IM    
Affiliation:
Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, 5 Bartla St., 51-618, Wroclaw, Poland.
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