| Occupationally-induced scleroderma. | |
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MedLine Citation:
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PMID: 1313094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis or scleroderma is an uncommon multisystem disease with a reported incidence of 2 to 12 cases per million people per year. The clinical and pathological features can be grouped into three main categories: those related to fibrosis, to vascular abnormalities, and to immunological abnormalities. Cutaneous features dominate the patients' appearance, and Raynaud's phenomenon is an early symptom. A possible association between scleroderma and workers exposed to hand-arm vibration and/or silica has been suggested by reports in the literature since the turn of the century. A further four patients with collagen disease are reported here. Three were occupationally exposed to both hand-arm vibration and silica, the fourth to hand-arm vibration alone. In conjunction with previously reported cases, this supports the hypothesis that collagen disease may be work attributable in hypersusceptible persons. |
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Authors:
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P L Pelmear; J O Roos; W M Maehle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of occupational medicine. : official publication of the Industrial Medical Association Volume: 34 ISSN: 0096-1736 ISO Abbreviation: J Occup Med Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7502807 Medline TA: J Occup Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 20-5 Citation Subset: IM |
Affiliation:
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Occupational Health and Safety Branch Chest Clinic, Ministry of Labour, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fibrosis Humans Male Middle Aged Occupational Diseases / etiology*, pathology Scleroderma, Systemic / etiology*, pathology Silicon Dioxide / adverse effects Vibration / adverse effects* |
| Chemical | |
Reg. No./Substance:
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7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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