Document Detail

Occupational lead exposure: studies in two brothers showing differential susceptibility to lead.
MedLine Citation:
PMID:  4017220     Owner:  NLM     Status:  MEDLINE    
Unexpected differences in clinical and biochemical findings in two brothers occupationally exposed to the same source of lead for dissimilar lengths of time are presented. Only the brother with the shorter period of lead exposure was anemic and afflicted by nausea, vomiting, abdominal colic and arthralgia. His urinary PBG output yielded the high orders of magnitude found in acute intermittent porphyria in relapse. Prior to administration of a single dose of EDTA (1 g of the calcium disodium salt given intravenously in 325 mL 0.15 mol/L NaCl), his blood lead levels averaged 3.6 mumol/L. The amount of chelatable lead retrieved from his urine, 31 mumol/day, was more than twice that found in his asymptomatic counterpart who was exposed to lead for 13 months and whose pre-EDTA blood lead levels averaged 4.0 mumol/L. Not only the activity of delta-aminolaevulinic acid dehydratase, but also that of uroporphyrinogen I synthetase, was markedly inhibited by lead in red cells of both brothers. These activities were restored to normal levels in vitro by addition to the assay system of zinc and dithiothreitol. This ruled out a coexisting genetic deficiency of either enzyme. The anemia of the symptomatic brother with the shorter period of lead exposure was alleviated by folic acid, 15 mg/day. The differences in findings between the two brothers point to differential susceptibility to lead and illustrate the extent to which symptomatic lead poisoning may mimic biochemical and clinical features of the acute porphyrias.
H L Haust; H C Poon; M Inwood; E K O'Hea; D S Haines; C J Forret; D S Keys
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  18     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-09-23     Completed Date:  1985-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
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MeSH Terms
Aminolevulinic Acid / urine
Environmental Exposure
Hydroxymethylbilane Synthase / blood
Lead / blood
Lead Poisoning / genetics*
Metals / urine
Occupational Diseases / genetics*
Porphobilinogen / urine
Porphobilinogen Synthase / blood
Reg. No./Substance:
0/Metals; 106-60-5/Aminolevulinic Acid; 487-90-1/Porphobilinogen; 7439-92-1/Lead; EC Synthase; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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