Document Detail


Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies.
MedLine Citation:
PMID:  17153843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic and experimental research suggests a potential role of occupational exposures in the development of systemic lupus erythematosus (SLE). A plausible association has been identified in studies of occupational silica exposure and SLE, complemented by experimental studies in lupus-prone mice exploring potential mechanisms related to apoptosis and immune dysregulation. Experimental studies of the solvent trichloroethylene in lupus-prone mice provide evidence of effects on immune function, including increased production of autoantibodies and activation of CD4+ T cells. However, few studies of occupational solvent exposure and SLE have been conducted, and those that are available show little evidence of an association. There is some suggestion from the available studies of the potential influence of pesticides on SLE, but as with solvents, the specific type of pesticides that may be implicated is not known. Our understanding of the role of occupational exposures in SLE could be advanced by the development of larger, multisite or parallel studies that utilize similar questionnaire and exposure evaluation methods. Multiple studies using comparable exposure measures are needed to provide sufficient sample size for examining gene-environment interactions. We provide a general overview of data requirements and methods available for the assessment and evaluation of occupational exposures in clinical and population-based studies of SLE.
Authors:
C G Parks; G S Cooper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  15     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  728-36     Citation Subset:  IM    
Affiliation:
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. cop8@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Clinical Trials as Topic / methods,  trends
Evidence-Based Medicine
Humans
Immune System / drug effects
Lupus Erythematosus, Systemic / epidemiology*,  etiology*,  immunology,  physiopathology
Occupational Exposure / adverse effects*
Pesticides / adverse effects
Risk Assessment
Risk Factors
Silicon Dioxide / adverse effects
Solvents / adverse effects
Chemical
Reg. No./Substance:
0/Pesticides; 0/Solvents; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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