| Occupational exposures and risk of gastric cancer in a population-based case-control study. | |
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MedLine Citation:
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PMID: 10606238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric cancer trends seem to follow improvements in the environment of blue-collar workers, but the etiological role of occupational exposures in gastric carcinogenesis is scantily investigated. The risk of gastric adenocarcinoma in 10 common occupational industries, and particularly the long-term effects of asbestos, organic solvents, impregnating agents, insecticides, and herbicides, were evaluated in a population-based case-control study, including data on most established risk factors. The study base included all individuals of ages 40-79, born in Sweden and living in either of two areas (total population, 1.3 million) with differing gastric cancer incidences, from February 1989 through January 1995. We interviewed 567 cases classified to site (cardia/noncardia) and histological type, and 1,165 population-based controls, frequency-matched for age and sex. Metal workers had a 46% excess gastric cancer risk [adjusted odds ratio (OR), 1.46; 95% confidence interval (CI), 1.10-1.94], increasing to 1.65 (95% CI, 1.17-2.32) for >10 years in the industry. The elevated risk after exposure to herbicides (OR, 1.56; 95% CI, 1.13-2.15) was attributable to phenoxyacetic acids (adjusted OR, 1.70; 95% CI, 1.16-2.48), similarly across tumor subtypes, and not modified by smoking, body mass index, or Helicobacter pylori. The absence of interaction was demonstrated by the pure multiplicative effect found among those exposed to both H. pylori and phenoxyacetic acids (OR, 3.42; 95% CI, 1.41-8.26). Organic solvents, insecticides, impregnating agents, and asbestos were not associated with gastric cancer risk. Employment in the metal industry and exposure to phenoxyacetic acids were both positively and independently associated with gastric cancer risk. The fractions of all gastric cancers attributable to these job-related exposures were small but not negligible (7 and 5%, respectively) in the Swedish population. |
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Authors:
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A M Ekström; M Eriksson; L E Hansson; A Lindgren; L B Signorello; O Nyrén; L Hardell |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 59 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-01-06 Completed Date: 2000-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5932-7 Citation Subset: IM |
Affiliation:
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Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. Annamia.Ekstrom@mep.ki.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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classification,
epidemiology*,
etiology Adult Age Factors Aged Case-Control Studies Female Humans Incidence Interviews as Topic Male Middle Aged Occupational Exposure* Risk Factors Sex Factors Stomach Neoplasms / classification, epidemiology*, etiology Sweden / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA 50959/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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