Document Detail

Occupational exposures and chronic respiratory symptoms. A population-based study.
MedLine Citation:
PMID:  3497594     Owner:  NLM     Status:  MEDLINE    
Data from a random sample of 8,515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared with unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR = 1.53, 95% Cl = 1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory symptoms and disease can be independently associated with occupational exposures.
R J Korn; D W Dockery; F E Speizer; J H Ware; B G Ferris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  136     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-17     Completed Date:  1987-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  AIM; IM    
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MeSH Terms
Air Pollutants, Occupational / adverse effects*
Chronic Disease
Cross-Sectional Studies
Dust / adverse effects
Environmental Exposure*
Gases / adverse effects
Lung Diseases, Obstructive / etiology
Middle Aged
Respiratory Tract Diseases / chemically induced*
Grant Support
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Dust; 0/Gases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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