| Occupational exposure to glycol ethers and human congenital malformations. | |
| | |
MedLine Citation:
|
PMID: 12819971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This commentary reviews toxicological information and critically evaluates epidemiological information on the relationship between glycol ethers and congenital malformations. METHODS: The authors identified and assessed toxicological and epidemiological research on glycol ethers used in occupational settings and congenital malformations. Sensitivity analyses evaluated the possible role of methodological problems in explaining the findings of the epidemiological studies. RESULTS: Exposure to certain glycol ethers, including ethylene glycol monomethyl ether and ethylene glycol mono-ethyl ether, throughout the period of major organogenesis, has induced malformations of many organ systems in some of the animal models studied. Other glycol ethers, including ethylene glycol butyl and propyl ethers and most propylene glycol ethers, have not induced fetal malformations in the animal models studied. Four epidemiological studies have assessed the relationship between occupational exposure to glycol ethers and congenital malformations in humans. One study was uninformative because of small numbers, two found a positive association between glycol ethers and malformations of a number of different organs, and one found no association with neural-tube defects. Sensitivity analyses indicated that the results of the latter three investigations could be due to methodological problems. The positive studies, further, lack biological plausibility, in that the glycol ethers to which the subjects were exposed have not been, for the most part, teratogenic in the animal models that have been studied. CONCLUSIONS: The current evidence is insufficient for one to determine whether occupational exposure to glycol ethers causes human congenital malformations. We suggest that future studies quantify the effect of methodological problems on study results, using methods such as validation studies and sensitivity analysis. |
| | |
Authors:
|
George Maldonado; Elizabeth Delzell; Rochelle W Tyl; Lowell E Sever |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2003-06-19 |
Journal Detail:
|
Title: International archives of occupational and environmental health Volume: 76 ISSN: 0340-0131 ISO Abbreviation: Int Arch Occup Environ Health Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-08-04 Completed Date: 2004-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7512134 Medline TA: Int Arch Occup Environ Health Country: Germany |
Other Details:
|
Languages: eng Pagination: 405-23 Citation Subset: IM |
Affiliation:
|
School of Public Health, University of Minnesota, 420 Delaware St. SE, Mayo Mail Code 807, Minneapolis, MN 55455-0392, USA. GMPhD@umn.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced
/
epidemiology*,
etiology* Animals Ethylene Glycols / chemistry, metabolism, toxicity* Female Humans Maternal Exposure / adverse effects Occupational Exposure / adverse effects* Pregnancy Propylene Glycols / chemistry, metabolism, toxicity |
| Chemical | |
Reg. No./Substance:
|
0/Ethylene Glycols; 0/Propylene Glycols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical management of proximal bile duct cancer: extended right lobe resection increases resectabil...
Next Document: In vitro percutaneous absorption of cobalt.