| Occupational exposure to endocrine disruptors and time to pregnancy among couples in a large birth cohort study: the Generation R Study. | |
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MedLine Citation:
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PMID: 21392747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the influence of occupational exposure to endocrine disruptors (EDs) on time to pregnancy (TTP). DESIGN: Cross-sectional analysis within a prospective, population-based cohort study. SETTING: Medical center. PATIENT(S): Mothers and fathers who filled out a questionnaire during mid-pregnancy (response 77% and 82% of enrollment, respectively) were selected if the pregnancy was planned and either parent performed paid employment. In total, 2,774 mothers and 2,728 partners were included in the statistical analyses. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Self-reported TTP (months). RESULT(S): There was no correlation between maternal and paternal exposure, because κ values for agreement for all exposure categories ranged from 0.03 to 0.13. Paternal occupational exposure to heavy metals (hazard ratio of pregnancy 0.83; 95% confidence interval 0.71-0.97) and overall exposure to EDs (hazard ratio 0.85; 95% confidence interval 0.75-0.96) was statistically significantly associated with an increased TTP. Maternal occupational exposure to all categories of EDs showed prolonged TTP, but the decreased hazard ratios were not statistically significant. CONCLUSION(S): This birth cohort study provides indications for adverse effects of parental occupational exposure to EDs on TTP. |
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Authors:
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Claudia A Snijder; Marijn M Brouwers; Vincent W V Jaddoe; Albert Hofman; Nel Roeleveld; Alex Burdorf |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-10 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: 2011-06-21 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2067-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Generation R Study Group Erasmus Medical Center, Department of Public Health, Rotterdam, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Birth Intervals / statistics & numerical data Birth Rate* Cohort Studies Cross-Sectional Studies Endocrine Disruptors / adverse effects* Family Characteristics* Female Humans Male Occupational Exposure / adverse effects*, statistics & numerical data Pregnancy Pregnancy Rate* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endocrine Disruptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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