Document Detail

Occupational exposure to endocrine disruptors and time to pregnancy among couples in a large birth cohort study: the Generation R Study.
MedLine Citation:
PMID:  21392747     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the influence of occupational exposure to endocrine disruptors (EDs) on time to pregnancy (TTP).
DESIGN: Cross-sectional analysis within a prospective, population-based cohort study.
SETTING: Medical center.
PATIENT(S): Mothers and fathers who filled out a questionnaire during mid-pregnancy (response 77% and 82% of enrollment, respectively) were selected if the pregnancy was planned and either parent performed paid employment. In total, 2,774 mothers and 2,728 partners were included in the statistical analyses.
MAIN OUTCOME MEASURE(S): Self-reported TTP (months).
RESULT(S): There was no correlation between maternal and paternal exposure, because κ values for agreement for all exposure categories ranged from 0.03 to 0.13. Paternal occupational exposure to heavy metals (hazard ratio of pregnancy 0.83; 95% confidence interval 0.71-0.97) and overall exposure to EDs (hazard ratio 0.85; 95% confidence interval 0.75-0.96) was statistically significantly associated with an increased TTP. Maternal occupational exposure to all categories of EDs showed prolonged TTP, but the decreased hazard ratios were not statistically significant.
CONCLUSION(S): This birth cohort study provides indications for adverse effects of parental occupational exposure to EDs on TTP.
Claudia A Snijder; Marijn M Brouwers; Vincent W V Jaddoe; Albert Hofman; Nel Roeleveld; Alex Burdorf
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-10
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-20     Completed Date:  2011-06-21     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2067-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Generation R Study Group Erasmus Medical Center, Department of Public Health, Rotterdam, the Netherlands.
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MeSH Terms
Birth Intervals / statistics & numerical data
Birth Rate*
Cohort Studies
Cross-Sectional Studies
Endocrine Disruptors / adverse effects*
Family Characteristics*
Occupational Exposure / adverse effects*,  statistics & numerical data
Pregnancy Rate*
Time Factors
Reg. No./Substance:
0/Endocrine Disruptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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