Document Detail


Occupational exposure to benzene and changes in hematological parameters and urinary trans, trans-muconic acid.
MedLine Citation:
PMID:  23279797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: For its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. However, there is little knowledge about the effect of benzene metabolites on hematological parameters.
OBJECTIVE: To evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-MA), a benzene metabolite, and some hematological parameters in gasoline workers.
METHODS: We studied 102 gasoline station workers from 11 gasoline stations in Pathumwan district, central area of Bangkok, Thailand. Their blood and urine samples were analyzed for some hematological parameters and urinary t, t-MA analysis by high performance liquid chromatography (HPLC).
RESULTS: We found an inverse correlation between urinary t, t-MA concentration and hemoglobin level (r = 0.281, p<0.05), hematocrit (r = 0.264, p<0.05). Those with higher urinary t, t-MA had a significantly (p<0.05) lower eosinophil counts than those with lower exposure. No significant correlation was found between urinary t, t-MA level and other white blood cell parameters and platelets count.
CONCLUSION: Exposure to benzene would cause bone marrow depression presenting as drop in hemoglobin, hematocrit and eosinophil counts.
Authors:
T Tunsaringkarn; S Soogarun; A Palasuwan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of occupational and environmental medicine     Volume:  4     ISSN:  2008-6520     ISO Abbreviation:  Int J Occup Environ Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-04-30     Revised Date:  2013-05-14    
Medline Journal Info:
Nlm Unique ID:  101535763     Medline TA:  Int J Occup Environ Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Affiliation:
The College of Public Health Sciences, Chulalongkorn University, Thailand. tkalayan@chula.ac.th.
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MeSH Terms
Descriptor/Qualifier:
Benzene / metabolism*
Blood Cell Count
Hematocrit
Hemoglobins / analysis
Humans
Occupational Exposure* / statistics & numerical data
Sorbic Acid / analogs & derivatives*,  metabolism
Chemical
Reg. No./Substance:
0/Hemoglobins; 110-44-1/Sorbic Acid; 3KD92ZL2KH/muconic acid; 71-43-2/Benzene
Comments/Corrections
Comment In:
Int J Occup Environ Med. 2013 Apr;4(2):110
Int J Occup Environ Med. 2013 Apr;4(2):109-10   [PMID:  23567538 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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