Document Detail

Occupational exposure to aromatic hydrocarbons at a coke plant: Part I. Identification of hydrocarbons in air and their metabolites in urine by a gas chromatography-mass spectrometry method.
MedLine Citation:
PMID:  15215657     Owner:  NLM     Status:  MEDLINE    
A method for the qualitative analysis of aromatic hydrocarbons in air and their various urinary metabolites is presented. The air was sampled in charcoal tubes and extracted with carbon disulfide. The hydrocarbons were identified as being aliphatic hydrocarbons (C(9)-C(19)), aromatic hydrocarbons and heterocyclic compounds. The urinary metabolites after enzymatic hydrolysis were analyzed by solid-phase extraction with a styrene-divinylbenzene resin, silylation with N,O-bis(trimethylsilyl)acetamide and GC/MS for separation and detection. Satisfactory separation of all compounds investigated was achieved without interference due to matrix peaks. The following compounds were identified in the urine of workers: dimethylphenol isomers, 4-ethyl-1,3-benzenediol, 2-ethoxybenzoic acid and methoxyphenols. Trimethylsilyl derivatives of aromatic hydroxyacids and hydroxymethoxyacids were found in the urine of occupationally exposed workers by means of a silylation procedure.
Grazyna Bieniek; Slawomir Kurkiewicz; Tadeusz Wilczok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational health     Volume:  46     ISSN:  1341-9145     ISO Abbreviation:  J Occup Health     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Department of Molecular Biology, Biochemistry and Biopharmacy, Faculty of Pharmacy, Medical University of Silesia, Sosnowiec, Poland.
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MeSH Terms
Air Pollutants / isolation & purification,  urine*
Benzene / isolation & purification
Gas Chromatography-Mass Spectrometry / methods*
Heterocyclic Compounds / isolation & purification,  urine
Hydrocarbons, Alicyclic / isolation & purification,  urine
Hydrocarbons, Aromatic / isolation & purification,  urine*
Hydroxybenzoic Acids / isolation & purification,  urine
Middle Aged
Naphthalenes / isolation & purification,  urine
Occupational Exposure / analysis*
Toluene / isolation & purification,  urine
Xylenes / isolation & purification,  urine
Reg. No./Substance:
0/Air Pollutants; 0/Coke; 0/Heterocyclic Compounds; 0/Hydrocarbons, Alicyclic; 0/Hydrocarbons, Aromatic; 0/Hydroxybenzoic Acids; 0/Naphthalenes; 0/Xylenes; 108-88-3/Toluene; 134-11-2/2-ethoxybenzoic acid; 71-43-2/Benzene; 91-20-3/naphthalene

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