Document Detail


Occupational causes of sarcoidosis.
MedLine Citation:
PMID:  22314258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Sarcoidosis, the multiorgan granulomatous disease of unknown cause, remains mysterious. Several important investigations in the past 2 years add to the accumulating evidence for both occupational and environmental causes of granulomatous inflammation.
RECENT FINDINGS: This review considers the most recent studies that contribute to the hypothesis that sarcoidosis occurs when individuals are exposed to foreign antigens and to inorganic particulates that promote inflammation. Major recent findings, such as those emerging from the study of World Trade Center responders, the study of nanoparticles, and cases of work-associated sarcoidosis, support the probability that occupational, as well as environmental, exposures to inflammatory stimuli trigger sarcoidosis-like illness. Major recent studies of microbially rich indoor environments, including moldy indoor workplaces and mycobacterially contaminated settings, contribute to the evidence that a variety of microbial antigens serve as targets for the hypersensitivity immune response in an inflammatory milieu.
SUMMARY: There is increasing evidence that sarcoidosis can occur in workplace settings in which there is exposure to both foreign antigens and inorganic triggers of inflammation that promote an exuberant granulomatous immune response. It is likely that sarcoidosis has more than one cause.
Authors:
Kira L Newman; Lee S Newman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  12     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-07-13     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Bacterial / immunology,  toxicity
Antigens, Fungal / immunology,  toxicity
Environmental Exposure
Female
Humans
Hypersensitivity / etiology,  immunology
Male
Mice
Mycobacterium Infections / immunology
Occupational Diseases / etiology*,  immunology
Occupational Exposure
Particulate Matter / immunology,  toxicity
Sarcoidosis / etiology*,  immunology
Grant Support
ID/Acronym/Agency:
P01 ES011810/ES/NIEHS NIH HHS; P01 ES011810/ES/NIEHS NIH HHS; P01 ES011810-08/ES/NIEHS NIH HHS; P01 ES011810-09/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, Fungal; 0/Particulate Matter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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