Document Detail

Occupational asthma in antibiotic manufacturing workers: case reports and systematic review.
MedLine Citation:
PMID:  21603168     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5-8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required.
Sara Díaz Angulo; Joanna Szram; Jenny Welch; Julie Cannon; Paul Cullinan
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Publication Detail:
Type:  Journal Article     Date:  2011-03-17
Journal Detail:
Title:  Journal of allergy     Volume:  2011     ISSN:  1687-9791     ISO Abbreviation:  J Allergy (Cairo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-07-14     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  101535174     Medline TA:  J Allergy (Cairo)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365683     Citation Subset:  -    
Centro Medico de Asturias, Avendia José María Richard, Oviedo, 33193 Asturias, Spain.
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