| Occupational asthma in antibiotic manufacturing workers: case reports and systematic review. | |
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MedLine Citation:
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PMID: 21603168 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5-8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required. |
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Authors:
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Sara Díaz Angulo; Joanna Szram; Jenny Welch; Julie Cannon; Paul Cullinan |
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Publication Detail:
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Type: Journal Article Date: 2011-03-17 |
Journal Detail:
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Title: Journal of allergy Volume: 2011 ISSN: 1687-9791 ISO Abbreviation: J Allergy (Cairo) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101535174 Medline TA: J Allergy (Cairo) Country: United States |
Other Details:
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Languages: eng Pagination: 365683 Citation Subset: - |
Affiliation:
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Centro Medico de Asturias, Avendia José María Richard, Oviedo, 33193 Asturias, Spain. |
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