Document Detail

Occupational asthma due to heated polypropylene.
MedLine Citation:
PMID:  8162997     Owner:  NLM     Status:  MEDLINE    
A 35 year-old nonatopic woman was referred to the hospital for possible work-related asthma. She had worked as an operator, at a plant producing polypropylene bags, for the previous four yrs. Her main complaint was a productive cough with dyspnoea and wheezing, as well as rhinitis over the past 3 yrs. She had been absent from work for 6 months on maternity leave, and had improved greatly. She was on a beta 2-adrenergic agent and had to take it at least four times daily. Baseline spirometry whilst at work showed marked airflow obstruction (forced expiratory volume in one second (FEV1) of 43% predicted (pred). After two months away from work FEV1 improved to 89% pred; provocative concentration of histamine causing a 25% fall in FEV1 (PC20) was 3.6 (mild airway hyperresponsiveness). Return to work resulted in a marked deterioration in FEV1, and serial peak expiratory flow (PEFR) values. PC20 was 0.11 (severe airway hyperresponsiveness) one week after she had returned to work. Specific inhalation challenges with polypropylene heated to 250 degrees C resulted in a late asthmatic reaction. As formaldehyde is one of the degradation products of heating polypropylene, we exposed her to it for up to 2 h, but we elicited no bronchospastic reaction. We conclude that heated polypropylene should be listed as one of the agents that causes occupational asthma.
J L Malo; A Cartier; L Pineault; M Dugas; A Desjardins
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  7     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-26     Completed Date:  1994-05-26     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  IM    
Dept of Chest Medicine, Höpital du Sacré-Coeur, Montreal, Canada.
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MeSH Terms
Asthma / chemically induced*,  physiopathology
Bronchial Hyperreactivity / physiopathology
Bronchial Provocation Tests
Hot Temperature
Occupational Diseases / chemically induced*,  physiopathology
Occupational Exposure / adverse effects*
Polypropylenes / adverse effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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