Document Detail


Occupational asthma due to heated polypropylene.
MedLine Citation:
PMID:  8162997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 35 year-old nonatopic woman was referred to the hospital for possible work-related asthma. She had worked as an operator, at a plant producing polypropylene bags, for the previous four yrs. Her main complaint was a productive cough with dyspnoea and wheezing, as well as rhinitis over the past 3 yrs. She had been absent from work for 6 months on maternity leave, and had improved greatly. She was on a beta 2-adrenergic agent and had to take it at least four times daily. Baseline spirometry whilst at work showed marked airflow obstruction (forced expiratory volume in one second (FEV1) of 43% predicted (pred). After two months away from work FEV1 improved to 89% pred; provocative concentration of histamine causing a 25% fall in FEV1 (PC20) was 3.6 mg.ml-1 (mild airway hyperresponsiveness). Return to work resulted in a marked deterioration in FEV1, and serial peak expiratory flow (PEFR) values. PC20 was 0.11 mg.ml-1 (severe airway hyperresponsiveness) one week after she had returned to work. Specific inhalation challenges with polypropylene heated to 250 degrees C resulted in a late asthmatic reaction. As formaldehyde is one of the degradation products of heating polypropylene, we exposed her to it for up to 2 h, but we elicited no bronchospastic reaction. We conclude that heated polypropylene should be listed as one of the agents that causes occupational asthma.
Authors:
J L Malo; A Cartier; L Pineault; M Dugas; A Desjardins
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  7     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-26     Completed Date:  1994-05-26     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  IM    
Affiliation:
Dept of Chest Medicine, Höpital du Sacré-Coeur, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / chemically induced*,  physiopathology
Bronchial Hyperreactivity / physiopathology
Bronchial Provocation Tests
Female
Hot Temperature
Humans
Occupational Diseases / chemically induced*,  physiopathology
Occupational Exposure / adverse effects*
Polypropylenes / adverse effects*
Spirometry
Chemical
Reg. No./Substance:
0/Polypropylenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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