Document Detail

Occupational allergic rhinoconjunctivitis and asthma to goat and cross-reactivity with cow epithelium.
MedLine Citation:
PMID:  16680929     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The development of sensitization and symptoms after the inhalation of epithelial allergens is common. OBJECTIVES: To investigate the allergic response (in vivo and in vitro) of 3 individuals clinically sensitive and occupationally exposed to cow and goat and to evaluate the allergenic cross-reactivity between cow and goat epithelium extracts. METHODS: Three patients--a butcher and 2 doctors in veterinary medicine--were evaluated. These patients reported allergic respiratory symptoms after occupational exposure to goats and cows. Extracts were prepared from epithelia of both animals. All the patients underwent organ-specific allergen challenges with cow and goat extracts. Four nasal and 2 bronchial challenges were conducted following standardized procedures. RESULTS: All 3 patients had positive challenge results with the offending allergen extract. Specific IgE to goat allergens was detected in all patients. Several IgE-binding bands were detected. Inhibition assays (enzyme allergosorbent test and immunoblots) confirmed moderate-to-high cross-reactivity between goat and cow extracts. CONCLUSIONS: We confirm clinical sensitivity and specific IgE binding to goat and cow allergens in occupationally exposed individuals. There was good correlation among the clinical history, exposure, and the laboratory findings.
Angel Ferrer; Jerónimo Carnés; F M Marco; Carmen Andréu; Enrique Fernández-Caldas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  96     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-85     Citation Subset:  IM    
Allergy Department, Hospital de la Vega Baja, Orihuela, Alicante, Spain.
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MeSH Terms
Asthma / etiology,  immunology*
Bronchial Provocation Tests
Cattle / immunology*
Conjunctivitis, Allergic / etiology,  immunology*
Cross Reactions
Epithelium / chemistry,  immunology*
Goats / immunology*
Immunoglobulin E / blood
Occupational Diseases
Occupational Exposure
Rhinitis, Allergic, Perennial / etiology,  immunology*
Skin Tests
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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