Document Detail


Occupational allergic rhinoconjunctivitis and asthma to goat and cross-reactivity with cow epithelium.
MedLine Citation:
PMID:  16680929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The development of sensitization and symptoms after the inhalation of epithelial allergens is common. OBJECTIVES: To investigate the allergic response (in vivo and in vitro) of 3 individuals clinically sensitive and occupationally exposed to cow and goat and to evaluate the allergenic cross-reactivity between cow and goat epithelium extracts. METHODS: Three patients--a butcher and 2 doctors in veterinary medicine--were evaluated. These patients reported allergic respiratory symptoms after occupational exposure to goats and cows. Extracts were prepared from epithelia of both animals. All the patients underwent organ-specific allergen challenges with cow and goat extracts. Four nasal and 2 bronchial challenges were conducted following standardized procedures. RESULTS: All 3 patients had positive challenge results with the offending allergen extract. Specific IgE to goat allergens was detected in all patients. Several IgE-binding bands were detected. Inhibition assays (enzyme allergosorbent test and immunoblots) confirmed moderate-to-high cross-reactivity between goat and cow extracts. CONCLUSIONS: We confirm clinical sensitivity and specific IgE binding to goat and cow allergens in occupationally exposed individuals. There was good correlation among the clinical history, exposure, and the laboratory findings.
Authors:
Angel Ferrer; Jerónimo Carnés; F M Marco; Carmen Andréu; Enrique Fernández-Caldas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  96     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-85     Citation Subset:  IM    
Affiliation:
Allergy Department, Hospital de la Vega Baja, Orihuela, Alicante, Spain. aferrert@meditex.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Asthma / etiology,  immunology*
Bronchial Provocation Tests
Cattle / immunology*
Conjunctivitis, Allergic / etiology,  immunology*
Cross Reactions
Epithelium / chemistry,  immunology*
Female
Goats / immunology*
Humans
Immunoglobulin E / blood
Male
Occupational Diseases
Occupational Exposure
Rhinitis, Allergic, Perennial / etiology,  immunology*
Skin Tests
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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