Document Detail

Occupational allergic contact dermatitis from methyl aminolevulinate.
MedLine Citation:
PMID:  21781638     Owner:  NLM     Status:  MEDLINE    
Photodynamic therapy (PDT) is used to treat certain types of nonmelanoma skin cancer. Metvix cream applied topically in PDT is composed of the active substance methyl aminolevulinate and 14 excipients composing the vehicle. One case of occupational allergic contact dermatitis from methyl aminolevulinate is reported. A 49-year-old nurse's aide working in a PDT unit in the dermatology department developed a dermatitis involving the eyelids and fingers. The lesions began a few months after she started working in that unit. Patch tests were performed with the standard series (Spanish Group for Research into Dermatitis and Skin Allergies [GEIDAC]), cosmetics series, Metvix cream "as is," the Metvix vehicle supplied by the manufacturer, and some of the excipients separately (methyl para-hydroxybenzoate [Nipagin M], propyl para-hydroxybenzoate [Nipasol M], isopropyl myristate, cetostearyl alcohol [Lanette N], and disodium edetate). After day-2, day-4, and day-7 readings, positive results were achieved only with Metvix cream "as is." Tests performed on a control group of 15 individuals were negative. Literature on cases of allergic contact dermatitis from methyl aminolevulinate is reviewed. It should be emphasized that the present case is the first occupational case reported so far.
María Antonia Pastor-Nieto; Mercedes Olivares; Consuelo Sánchez-Herreros; Paulina Belmar; Esther De Eusebio
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatitis : contact, atopic, occupational, drug     Volume:  22     ISSN:  1710-3568     ISO Abbreviation:  Dermatitis     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-30     Revised Date:  2013-08-30    
Medline Journal Info:
Nlm Unique ID:  101207335     Medline TA:  Dermatitis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  216-9     Citation Subset:  IM    
Dermatology Department, Guadalajara University Hospital, C/ Donantes de Sangre s/n, Guadalajara, Spain.
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MeSH Terms
Aminolevulinic Acid / adverse effects,  analogs & derivatives*,  diagnostic use
Dermatitis, Allergic Contact / diagnosis*
Dermatitis, Occupational / diagnosis*,  etiology
Excipients / adverse effects,  diagnostic use
Middle Aged
Patch Tests
Photosensitizing Agents / adverse effects,  diagnostic use*
Reg. No./Substance:
0/Excipients; 0/Photosensitizing Agents; 0/methyl 5-aminolevulinate; 106-60-5/Aminolevulinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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