Document Detail


Occupational allergic contact dermatitis caused by sterile non-latex protective gloves: clinical investigation and chemical analyses.
MedLine Citation:
PMID:  23206313     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background An increased frequency of occupational contact hand dermatitis among surgical operating theatre personnel has been noticed. Objectives To evaluate patients with occupational contact dermatitis caused by their rubber gloves, and to describe a method for analysing the content of the allergens in the gloves. Materials and methods Patch tests were performed with the baseline series, a rubber chemical series, and the patients' own gloves. A method for analysing 1,3-diphenylguanidine (DPG) and cetylpyridinium chloride in the gloves was developed. Results Contact allergy to thiuram mix was found in 8 of 16 patients, whereas 12 of 16 patients reacted to DPG. In 7 of 8 patients, contact allergy to cetylpyridinium chloride was found. In the patients' gloves, cetylpyridinium chloride and DPG were detected at higher concentrations on the inside of the gloves than on the outside. Most patients had worked for decades in their present occupations, but their hand dermatitis had only been present for months. Conclusion Contact allergy to DPG in gloves has been disputed, but, in this study, we were able to confirm the presence of DPG and cetylpyridinium chloride in the causative gloves by using a modified method for the analysis. The presence of these chemicals in gloves caused an increase in occupational contact dermatitis in surgical operating theatre personnel.
Authors:
Ann Pontén; Nils Hamnerius; Magnus Bruze; Christer Hansson; Christina Persson; Cecilia Svedman; Kirsten Thörneby Andersson; Ola Bergendorff
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Contact dermatitis     Volume:  -     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden Department of Dermatology, Skåne University Hospital, SE-221 85 Lund, Sweden Department of Dermatology, Central Hospital, SE-291 85 Kristianstad, Sweden.
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