| Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation. | |
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MedLine Citation:
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PMID: 20407216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients having a generalised rash with severe liver dysfunction associated with exposure to trichloroethylene (TCE) have been reported mainly in Asian countries. However, no case has been reported in Japan since the 1990s. Here, we describe a case of hypersensitivity syndrome (HS) caused by TCE in a 30-year-old Japanese man. The patient developed a rash, fever and liver dysfunction 21 days after he had been exposed to TCE at his workplace. Serum human herpesvirus (HHV)-6 and cytomegalovirus (CMV) DNA were detected 4 and 7 weeks, respectively, after the onset; the IgG antibody titres to HHV-6 and CMV were significantly elevated 6 and 9 weeks, respectively, after the onset. Patch testing was positive for the metabolites of TCE (i.e. trichloroethanol, trichloroacetic acid and chloral hydrate) but not for TCE itself; these results suggest that the TCE metabolites induced this disease. Human leucocyte antigen-B*1301, which has been reported to be strongly associated with TCE-induced HS, was identified in this patient. In addition, the clinical findings, laboratory data and period of virus reactivation after onset were quite similar to those of drug-induced hypersensitivity syndrome (DIHS). We also review TCE-induced HS from the viewpoint of the similarity to DIHS in this article. |
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Authors:
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Hideaki Watanabe; Mikiko Tohyama; Michihiro Kamijima; Tamie Nakajima; Takemi Yoshida; Koji Hashimoto; Masafumi Iijima |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-21 |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 221 ISSN: 1421-9832 ISO Abbreviation: Dermatology (Basel) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Dermatology, Showa University School of Medicine, Tokyo, Japan. hwatanabe@med.showa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Viral / blood Cytomegalovirus Infections / chemically induced*, pathology DNA, Viral / blood Dermatitis, Occupational / drug therapy, etiology*, pathology Herpesvirus 6, Human / drug effects* Humans Hypersensitivity / drug therapy, etiology*, pathology Immunoglobulins / blood Male Prednisolone / therapeutic use Roseolovirus Infections / chemically induced*, pathology Solvents / toxicity* Trichloroethylene / toxicity* Virus Activation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulins; 0/Solvents; 50-24-8/Prednisolone; 79-01-6/Trichloroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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