Document Detail

Occupational Mn parkinsonism: magnetic resonance imaging and clinical patterns following CaNa2-EDTA chelation.
MedLine Citation:
PMID:  11130292     Owner:  NLM     Status:  MEDLINE    
We report a case of occupational parkinsonism due to manganese exposure in which professional exposure has been documented both by the high blood and urinary levels of the metal and by its presence in the materials used. A strong relation was evident among chelating treatment, cessation of exposure and clinical improvement. MRI confirmed the evolution of clinical pattern by means of reduction of heavy metal deposition in basal ganglia. These findings also agree with the few experimental and human studies published. This case study points to the need for an accurate occupational history collection and suggests the possibility of useful chelating therapy with CaNa2EDTA.
G Discalzi; E Pira; E Herrero Hernandez; C Valentini; M Turbiglio; F Meliga
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  21     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-6     Citation Subset:  IM    
Department of Occupational Health, Turin University, Italy.
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MeSH Terms
Antiparkinson Agents / therapeutic use*
Benserazide / therapeutic use
Brain / pathology
Chelating Agents / therapeutic use*
Edetic Acid / therapeutic use*
Globus Pallidus / pathology
Levodopa / therapeutic use
Magnetic Resonance Imaging
Manganese Poisoning / blood,  drug therapy,  etiology*
Metals, Heavy / blood
Middle Aged
Occupational Diseases / chemically induced*,  drug therapy
Occupational Exposure*
Parkinsonian Disorders / chemically induced*,  drug therapy*
Reg. No./Substance:
0/Antiparkinson Agents; 0/Chelating Agents; 0/Levodopa; 0/Metals, Heavy; 322-35-0/Benserazide; 60-00-4/Edetic Acid

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