Document Detail


Occupation and bladder cancer in a population-based case-control study in Northern New England.
MedLine Citation:
PMID:  20864470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk.
METHODS: Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial carcinoma of the bladder in 2001-2004, and from 1402 population controls. Unconditional logistic regression was used to calculate ORs and 95% CIs, adjusted for demographic factors, smoking and employment in other high-risk occupations.
RESULTS: Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR 2.2, 95% CI 1.4 to 3.4, p(trend) = 0.0065; metalworking/plasticworking machine operators: OR 1.6, 95% CI 1.01 to 2.6, p(trend) = 0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape industry workers; for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components manufacturing and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR 1.7, 95% CI 1.1 to 2.5).
CONCLUSIONS: Our findings support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder. Our results also corroborate many other previously reported associations between bladder cancer risk and various occupations. More detailed analyses using information from the study's job-specific questionnaires may help to identify MWF components that may be carcinogenic, and other bladder carcinogens associated with a variety of occupations.
Authors:
Joanne S Colt; Margaret R Karagas; Molly Schwenn; Dalsu Baris; Alison Johnson; Patricia Stewart; Castine Verrill; Lee E Moore; Jay Lubin; Mary H Ward; Claudine Samanic; Nathaniel Rothman; Kenneth P Cantor; Laura E Beane Freeman; Alan Schned; Sai Cherala; Debra T Silverman
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2010-09-23
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  68     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-07-18     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-49     Citation Subset:  IM    
Affiliation:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7240, USA. coltj@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Epidemiologic Methods
Female
Humans
Industry / statistics & numerical data
Male
Metallurgy / statistics & numerical data
Middle Aged
New England / epidemiology
Occupational Diseases / epidemiology,  etiology*
Occupational Exposure / adverse effects,  analysis
Occupations / statistics & numerical data
Sex Factors
Smoking / adverse effects,  epidemiology
Time Factors
Urinary Bladder Neoplasms / epidemiology,  etiology*
Grant Support
ID/Acronym/Agency:
Z99 CA999999/CA/NCI NIH HHS; ZIA CP010125-14/CP/NCI NIH HHS
Comments/Corrections

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