Document Detail

Occupation as a risk factor for uveal melanoma in Germany.
MedLine Citation:
PMID:  12199429     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study explored occupational risks linked to uveal melanoma. METHODS: The analysis pooled data from two case-referent studies (hospital- and population-based) conducted in Germany between 1995 and 1998, with incident cases matched with several referents by age, gender, and region of residence. The subjects were contacted through personal or telephone interviews. Their exposure status was based on their occupational history. Dichotomous coding for the main task and categorization into different occupational classification systems was performed. Altogether of 118 cases and 475 referents were included. Adjusted odds ratios were calculated by conditional logistic regression. RESULTS: Relevant occupations included food, beverage, and tobacco processors [odds ratio (OR) 4.7, 95% confidence interval (95% CI) 0.99-22.0] and miners (OR 2.3, 95% CI 0.92-5.99) among the men and station, engine and heavy equipment operators and freight handlers (OR 2.5, 95% CI 0.94-6.58) and medical, dental, pharmaceutical and veterinary workers (OR 2.1, 95% CI 0.71-6.02) among the women according to the International Standard Classification of Occupations, whereas, according to the European Industrial Classification, the relevant occupations were the food industry (OR 3.4, 95% CI 1.08-10.5) and the chemical and pharmaceutical industry (OR 2.8, 95% CI 1.01-7.78) among the men and machine production (OR 3.2, 95% CI 0.96-10.7) and health and veterinary sector (OR 2.4, 95% CI 0.97-5.71) among the women. CONCLUSIONS: These analyses support the potential role of occupational exposure as a risk factor for uveal melanoma. The findings must be interpreted carefully since the exposure was assessed indirectly.
Joel Monárrez-Espino; Andreas Stang; Katja Bromen; Hiltrud Merzenich; Gerasimos Anastassiou; Karl-Heinz Jöckel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  28     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-29     Completed Date:  2002-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany.
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MeSH Terms
Case-Control Studies
Germany / epidemiology
Logistic Models
Melanoma / epidemiology*
Middle Aged
Occupational Exposure*
Occupations / classification*
Odds Ratio
Risk Factors
Uveal Neoplasms / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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