Document Detail

Occult medullary carcinoma of thyroid with lymph node metastases: a case report.
MedLine Citation:
PMID:  18323285     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Occult thyroid malignancies presenting with secondary neck masses as the first clinical manifestation is well known. Although rare, medullary carcinoma serves a potential source for lymph node metastases. The characteristic cytomorphology of medullary thyroid carcinoma (MTC) should clinch the diagnosis. Further, fine needle aspiration cytology (FNAC) of the ultrasonography-detected occult nodules in thyroid serves as a useful preoperative diagnostic tool. CASE: A 22-year-old man presented with left-sided neck masses of 1 year duration. FNAC smears of the neck masses revealed cytomorphology characteristic of MTC. Ultrasonography of the thyroid led to ruling out the presence of an occult nodule and detected an 8-mm nodule in the left thyroid lobe. Ultrasound-guided FNAC of the nodule showed features similar to those with FNAC of the neck masses. Surgical resection of thyroid and neck masses further confirmed the diagnosis of a primary occult MTC with lymph node metastases. CONCLUSION: FNAC smears of lymph node masses showing the distinct cytomorphology of MTC should prompt suspicion for occult primary in thyroid. Ultrasound-guided FNAC of these occult nodules, if detected, further serves a diagnostic tool for accurate preoperative diagnosis when metastasis presents as the first clinical manifestation of an occult primary.
Sangeeta Kini; Chinmay K Saraf; Leena P Naik; Vimla B Shah; Gururaj V Puranik; Prema K Vartakvi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  52     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
Departmentof Pathology, BYL Nair Hospital and TN Medical College, Mumbai, India.
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MeSH Terms
Biopsy, Fine-Needle
Carcinoma, Medullary / diagnosis*,  pathology
Lymph Nodes / pathology*
Lymphatic Metastasis
Thyroid Neoplasms / diagnosis*,  pathology

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