Document Detail


Occult hepatitis B virus infection in the setting of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection: clinically relevant or a diagnostic problem?
MedLine Citation:
PMID:  17457912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical relevance of occult hepatitis B virus (HBV) infection, defined as detectable HBV DNA serum/liver, in the absence of hepatitis B surface antigen (HBsAg), is unclear. We determined the prevalence of serum occult HBV infection in HIV/HCV co-infected patients enrolled in APRICOT, a randomized multinational trial that investigated the efficacy and safety of peginterferon alfa-2a (40 kDa) plus ribavirin for treatment of HCV. We also examined the effect of prior HBV exposure to liver histology at baseline. Only HBsAg-negative patients were eligible. At screening, serum HBV DNA was assessed by commercial assay (detection limit = 200 copies/mL). Patients were divided into four serological groups: anti-HBs+/anti-HBc+; anti-HBs-/anti-HBc+; anti-HBs+/ anti-HBc-; anti-HBs-/anti-HBc-. Baseline liver biopsy grade and stage were compared among groups. Serum HBV DNA was undetectable in all patients, (n = 866). Results of anti-HBs and anti-HBc was available for 176 patients: 60 (34.1%) anti-HBs+/anti-HBc+; 60 (34.1%) anti-HBs-/anti-HBc+; 11 (6.3%) anti-HBs+/anti-HBc-; 45 (25.6%) anti-HBs-/anti-HBc-. There were no differences among the groups in the histological grade or stage at baseline liver biopsies. Occult HBV infection in serum was not detected in this large immunocompetent cohort. Moreover, prior exposure to HBV did not appear to have any affect on baseline liver histology.
Authors:
M Rodríguez-Torres; J Gonzalez-Garcia; N Bräu; R Solá; S Moreno; J Rockstroh; F Smaill; M C Mendes-Correa; J DePamphilis; F J Torriani;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  79     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Fundación de Investigación de Diego, Santurce, Puerto Rico. rodztorres@coqui.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
DNA, Viral / blood
Female
HIV / immunology
HIV Infections / blood,  complications*,  drug therapy,  virology
Hepacivirus / immunology
Hepatitis B / complications*,  diagnosis*
Hepatitis B Antibodies / blood
Hepatitis B Surface Antigens / blood
Hepatitis B virus / genetics
Hepatitis C / blood,  complications*,  drug therapy,  virology
Humans
Liver / pathology,  virology
Male
Middle Aged
Prevalence
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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