Document Detail

Occult choroidal neovascularization in adult-onset foveomacular vitelliform dystrophy.
MedLine Citation:
PMID:  11741106     Owner:  NLM     Status:  MEDLINE    
AIMS: To report 6 cases in which indocyanine green angiography (ICGA) failed to convert occult choroidal neovascularization (CNV) into well-defined CNV in adult-onset foveomacular vitelliform dystrophy (AOFVD). METHODS: Patients with AOFVD observed from 1993 to 1999 were prospectively followed up. Whenever the development of CNV was suspected, ICGA was performed to detect the precise location and extension of CNV by means of the IMAGEnet System. RESULTS: Six out of 51 patients (11.7%) developed CNV during the follow-up. The CNV was of the occult type, with an associated detachment of the pigment epithelium in 1 eye. On ICGA, a large hyperfluorescent lesion appeared after about 10 min, irregularly increasing with time, without a clear visualization of site and extension of CNV. CONCLUSIONS: In AOFVD, ICGA may fail to convert occult CNV into well-defined CNV, which is amenable to laser treatment, since hyperfluorescence caused by the probably vitelliform material binding to the ICG molecule and the CNV-induced hyperfluorescence cannot be angiographically distinguished from each other.
S Da Pozzo; M B Parodi; L Toto; G Ravalico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde     Volume:  215     ISSN:  0030-3755     ISO Abbreviation:  Ophthalmologica     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2001-12-13     Completed Date:  2002-01-15     Revised Date:  2007-09-17    
Medline Journal Info:
Nlm Unique ID:  0054655     Medline TA:  Ophthalmologica     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  412-4     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Eye Clinic, University of Trieste, Italy.
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MeSH Terms
Choroidal Neovascularization / diagnosis,  etiology*
Fluorescein Angiography
Indocyanine Green / diagnostic use
Middle Aged
Pigment Epithelium of Eye / pathology*
Prospective Studies
Retinal Diseases / complications*,  diagnosis
Reg. No./Substance:
3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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