| Occlusive and reperfused myocardial infarcts: differentiation with Mn-DPDP--enhanced MR imaging. | |
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MedLine Citation:
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PMID: 2500678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess whether the administration of manganese N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid (DPDP) permits differentiation between occlusive and reperfused infarcts, the authors subjected rats to either 6 hours of left coronary artery occlusion (n = 13) or 2 hours of occlusion followed by 4 hours of reperfusion (n = 10) before magnetic resonance (MR) imaging. Electrocardiographic-gated T1-weighted images were obtained before and for 1 hour after injection of 400 mumol/kg of Mn-DPDP. On T1-weighted images obtained before injection of Mn-DPDP. no significant differences in signal intensity were observed between normal and infarcted regions. Use of Mn-DPDP permitted delineation of the area of infarction. The pattern of enhancement in the injured zone was different for occlusive and reperfused myocardial infarcts. In rats with occlusive infarcts, In rats with occlusive infarcts, three well-defined zones were seen. Epicardium and endocardium were enhanced, while the midmyocardial zone was hypointense. The midmyocardial signal intensity gradually increased during the 60 minutes after injection. In rats with reperfused infarcts, the injured area was uniformly and intensely enhanced. Histologic examination confirmed the presence and location of myocardial infarct. Mn-DPDP may improve the detection and delineation of acute myocardial infarcts, demonstrate perfusion of the infarct, and permit discrimination between reperfused and occlusive infarcts. |
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Authors:
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M Saeed; S Wagner; M F Wendland; N Derugin; W E Finkbeiner; C B Higgins |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiology Volume: 172 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-03 Completed Date: 1989-08-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of California, San Francisco 94143. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Edetic Acid / analogs & derivatives*, diagnostic use Female Magnetic Resonance Imaging* / methods Myocardial Infarction / pathology* Myocardial Reperfusion* Myocardium / pathology Pyridoxal Phosphate / analogs & derivatives*, diagnostic use Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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T32 HL07570-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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