Document Detail

Occlusive hypertrophic arteritis as the cause of discrete necrosis in CNS toxoplasmosis in the acquired immunodeficiency syndrome.
MedLine Citation:
PMID:  3169729     Owner:  NLM     Status:  MEDLINE    
Brain specimens from five immunocompromised patients with CNS toxoplasmosis were studied with immunostaining for toxoplasma antigens and electron microscopy. The tachyzoites or toxoplasma antigens were predominantly localized in walls of hypertrophic, often thrombosed, arteries and adjacent brain tissue at the hyperemic rims of centrally necrotic lesions. This study suggests that in CNS toxoplasmosis of immunocompromised hosts, the organisms primarily invade and spread along segments of small artery walls, causing hypertrophy of arterial walls, thrombotic occlusion of lumens, circumscribed but expansive ischemic necrosis, and extravasation of organisms. Rapid response to chemotherapy can be explained by this preferential parasitism to the arterial walls. Early definitive diagnosis on brain biopsy specimens can be attained by immunostaining.
T E Huang; S M Chou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  19     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1210-4     Citation Subset:  IM; X    
Department of Pathology (Neuropathology), Cleveland Clinic Foundation, OH 44106.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  pathology
Arteritis / complications*,  pathology
Brain / blood supply*,  pathology
Brain Diseases / complications*,  pathology
Infarction / complications*,  pathology
Middle Aged
Toxoplasmosis / complications*,  pathology

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