Document Detail


Occlusions of epicardial arteries might not directly induce symptoms in ischemic heart disease.
MedLine Citation:
PMID:  10687898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is accepted that primary occlusions of epicardial arteries by thromboses, stenotic coronary artery disease (CAD), and spasm directly induce symptoms in ischemic heart disease (IHD). Because of this acceptance, there has been little interest in alternate mechanisms for IHD--as the spasm of resistance vessel (S-RV) concept of IHD, which asserts that S-RV directly induces symptoms in IHD. To stimulate interest in the S-RV concept, evidence against the primacy of occlusions of epicardial arteries was presented, as well as evidence for this position to provide a balanced discussion; while the evidence was mixed, overall findings appeared to weigh significantly against the primacy of occlusions of epicardial arteries. Also, the S-RV concept was discussed; the discussion included presenting the theory's explanations for events in epicardial arteries, with the aim of demonstrating that the concept provides more consistent explanations than the standard position. It is suggested that there is sufficient information to warrant renewed consideration of the S-RV concept.
Authors:
H R Hellstrom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  53     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-03-20     Completed Date:  2000-03-20     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-42     Citation Subset:  IM    
Affiliation:
Department of Pathology, Health Science Center at Syracuse, State University of New York, 13210, USA. hellstro@localnet.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / complications*
C-Reactive Protein / metabolism
Cholesterol / blood
Coronary Disease / complications
Coronary Vasospasm / complications
Humans
Models, Cardiovascular
Myocardial Infarction / etiology
Myocardial Ischemia / etiology*
Pericardium
Thrombosis / complications
Vascular Resistance
Vasoconstriction
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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