Document Detail

Occlusion pressure in acute bronchospasm induced by methylcholine.
MedLine Citation:
PMID:  705069     Owner:  NLM     Status:  MEDLINE    
We measured resting minute ventilation, the pressure developed by the inspiratory muscles during the first 0.1 sec of inspiratory effect against an occluded airway (P0.1), FRC and airway resistance in normal subjects during bronchoconstriction induced by methylcholine inhalation and again after the bronchoconstriction had been reversed by inhaled isoproterenol. Methylcholine resulted in a 2- to 3-fold increase in airway resistance, FRC rose in 5/6 subjects and ventilation changed in variable fashion. P0.1 increased in all subjects with methylcholine and decreased after isoproterenol. When the subjects were considred as a group, P0.1 correlated positively with airway resistance. Normal subjects respond to bronchoconstriction as they do to external resistance loading, by increasing inspiratory muscle activity. During bronchoconstriction, all subjects demonstrated an increase of breathing frequency and a decrease in the duration of expiration; inspiratory duration did not change significantly. This response may have been due to activity of pulmonary irritant receptors. Breathing frequency and expiratory duration returned to control levels with isoproterenol, so we could not show that this response was independent of changes in lung mechanics.
J Mann; C A Bradley; N R Anthonisen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  33     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  339-47     Citation Subset:  IM    
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MeSH Terms
Airway Resistance*
Bronchial Spasm / chemically induced,  physiopathology*
Functional Residual Capacity
Isoproterenol / pharmacology
Lung / physiopathology*
Methacholine Compounds
Reg. No./Substance:
0/Methacholine Compounds; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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