Document Detail


Occlusion of canine atrial appendage using an expandable silicone band.
MedLine Citation:
PMID:  20346467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Because the left atrial appendage is thought to be a major source of stroke in patients with atrial fibrillation, a new device and technique were developed for thoracoscopic isolation of the left atrial appendage. METHODS: The left and right atrial appendages were approached from an 11.5-mm port in the left thorax in 15 canines. With an atraumatic grasper for appendage positioning, expandable silicone bands covered with polyester fabric were placed at the base of the left and right atrial appendages. The location of the bands was marked with radiopaque clips to assess migration, and radiopaque dye was injected to confirm occlusion. The animals were killed at 1 week (n = 3), 2 weeks (n = 6), or 12 weeks (n = 6). RESULTS: The bands were deployed on 30 appendages without complications. The appendages were 100% occluded, and there was no migration of any bands at death. There was no indication of bleeding, rupture, or systemic emboli in any of the 15 animals. Following complete occlusion, the appendages became necrotic and were replaced by scar tissue. The healed atrial surface was consistently smooth and devoid of thrombus. There was evidence of mild-to-moderate inflammation associated with a foreign body-type reaction to the fabric material but no pericarditis. CONCLUSIONS: Permanent occlusion of the left atrial appendage is feasible via a thoracoscopic epicardial approach with this novel silicone band. As the atrial tissue becomes necrotic, the silicone band continues to constrict, ensuring that the appendage remains isolated. Band occlusion of the left atrial appendage could potentially improve overall treatment outcome in patients at high risk of atrial thrombus formation.
Authors:
Patrick M McCarthy; Richard Lee; Jessica L Foley; Lynette Phillips; Tessy Kanayinkal; David E Francischelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-25
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  140     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  885-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Affiliation:
Bluhm Cardiovascular Institute, Division of Cardiothoracic Surgery, Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital, Chicago, IL 60611-2908, USA. pmccart@nmh.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Appendage / pathology,  radiography,  surgery*
Cardiac Surgical Procedures / instrumentation*
Constriction
Dogs
Equipment Design
Female
Male
Necrosis
Silicones*
Thoracoscopy*
Time Factors
Chemical
Reg. No./Substance:
0/Silicones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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