| Occipital nerve stimulation in primary headache syndromes. | |
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MedLine Citation:
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PMID: 22276076 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Chronic daily headache is a major worldwide health problem that affects 3-5% of the population and results in substantial disability. Advances in the management of headache disorders have meant that a substantial proportion of patients can be effectively treated with medical treatments. However, a significant minority of these patients are intractable to conventional medical treatments. Occipital nerve stimulation (ONS) is emerging as a promising treatment for patients with medically intractable, highly disabling chronic headache disorders, including migraine, cluster headache and other less common headache syndromes. Open-label studies have suggested that this treatment modality is effective and recent controlled trial data are also encouraging. The procedure is performed using several technical variations that have been reviewed along with the complications, which are usually minor and tolerable. The mechanism of action is poorly understood, though recent data suggest that ONS could restore the balance within the impaired central pain system through slow neuromodulatory processes in the pain neuromatrix. While the available data are very encouraging, the ultimate confirmation of the utility of a new therapeutic modality should come from controlled trials before widespread use can be advocated; more controlled data are still needed to properly assess the role of ONS in the management of medically intractable headache disorders. Future studies also need to address the variables that are predictors of response, including clinical phenotypes, surgical techniques and stimulation parameters. |
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Authors:
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Giorgio Lambru; Manjit S Matharu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic advances in neurological disorders Volume: 5 ISSN: 1756-2864 ISO Abbreviation: Ther Adv Neurol Disord Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101480242 Medline TA: Ther Adv Neurol Disord Country: England |
Other Details:
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Languages: eng Pagination: 57-67 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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