| Occasional cigarette smoking chronically affects arterial function. | |
| | |
MedLine Citation:
|
PMID: 18799254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cigarette smoking is associated with impaired arterial function as measured by reduced vasodilation in response to reactive hyperemia. However, previous studies did not account for potential differences in shear stimuli. The purpose of this study was to use young, occasional smokers to ethically evaluate the effects of acute and chronic smoking on shear rate-diameter dose-response slopes. Young (20 to 26-y-old) nonsmokers (n = 9) and occasional (<1 pack/week) smokers were tested (n = 9). Smokers were tested after abstaining for 2 or more d and then immediately after smoking two cigarettes. Shear rate was manipulated using five upstream ischemic durations (0.5, 1, 2, 5 and 10 min). Radial artery blood velocities and diameters were assessed using Doppler ultrasound. Hierarchical linear modeling (HLM) was used to estimate change in diameter using repeated measures of shear rate nested within each subject. The shear rate-diameter slope was reduced by 35.9% in occasional smokers compared with nonsmoking controls (beta = 2.78(10-4) versus 1.78(10-4), p = 0.004). Acute smoking further attenuated the shear rate-diameter slope (i.e., arterial function) by 23.8% (beta = 1.79(10-4) versus 1.36(10-4), p = 0.037). These results suggest that repeated bouts of occasional cigarette smoking can chronically attenuate arterial function in otherwise healthy, young persons. |
| | |
Authors:
|
Lee Stoner; Manning J Sabatier; Christopher D Black; Kevin K McCully |
Related Documents
:
|
10516914 - Caffeine in coffee: its removal. why and how? 2272864 - The influence of user status and anxious disposition on the hypertensive effects of caf... 1416424 - Acute effect of cigarette smoking on the carbon monoxide diffusing capacity of the lung. 15894834 - Morning rise in blood pressure is a predictor of left ventricular hypertrophy in treate... 6362804 - Role of vasopressin in the control of arterial pressure. 8252694 - Effects of different training intensities on 24-hour blood pressure in hypertensive sub... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-16 |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 34 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-25 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 1885-92 Citation Subset: IM |
Affiliation:
|
Department of Kinesiology, University of Georgia, Athens, GA, USA. dr.l.stoner@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity Female Forearm / blood supply Hemorheology Humans Ischemia / physiopathology Male Radial Artery / physiopathology*, ultrasonography* Smoking / physiopathology* Ultrasonography, Doppler, Color / methods Vasodilation Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
HL65179/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel method for measuring electromechanical delay of the vastus medialis obliquus and vastus late...
Next Document: Desulfurization from thiophene by SO(4)(2-)/ZrO(2) catalytic oxidation at room temperature and atmos...